phases of Gastric secretion Flashcards
Gastric secretion occurs in 3 phases
Cephalic phase
Gastric phase
Intestinal phase
This phase occurs even before the food enters the stomach
Cephalic phase
The cephalic phase results from what?
smell
sight
thought
taste
appetite and stimulation relation
greater appetite, intense stimulation
Neurogenic signals originate in _________.
cerebral cortex and appetite centers of amygdala and hypothalamus
How are neurogenic signals from the cerebral cortex and appetite centers of the amygdala and hypothalamus transmitted?
dorsal motor nuclei of vagi —> vagus nerve –> stomach
The cephalic phase accounts for _____ of the gastric secretion associated with a meal
30%
This phase occurs when food enters the stomach
Gastric phase
When food enters the stomach, the following are excited:
- local nervous secretory reflex
- Vagal reflex
- Gastrin-histamine stimulation
Gastric secretions account for ______ of gastric acid secretion
60%
Occurs once the food is in the proximal small intestine
Intestinal phase
continuous small amounts of stomach secretion are partly due to _________.
gastrin released by duodenal mucosa
Intestinal phase accounts for _____ of the gastric acid
10%
Possible causes of Inhibition of gastric secretion
- presence of food in the small intestine
- the presence of food end-products, osmotic fluid, irritation
reflex initiated by the presence of food in the small intestine
reverse enterogastric reflex
What is the reverse enterogastric reflex?
slows gastric emptying upon small intestine filling
reverse enterogastric reflex is triggered by:
- distension of small bowel
- presence of acid in the upper intestine
- presence of protein breakdown products
- mucosal irritation
the presence of food end-products, osmotic fluid, and irritation causes the release of which hormone?
secretin
- glucose-dependent insulinotropic peptide
- vasoactive intestinal peptide
- somatostatin
secretin is important for?
pancreatic secretion
What does Secretin oppose?
gastric secretion
What is interdigestive state?
small amounts of gastric juice are secreted even with little to no digestion occurring
Interdigestive state secretion content
- mainly mucus
- no Acid
- a small amount of pepsin
Stimuli that can increase inter-digestive secretion
Emotional stimuli
Emotional stimuli increase interdigestive secretion to _______________.
> or = to 50 mL/hr, mostly peptic/acidic
- similar to cephalic phase
An increase in inter-digestive secretion may contribute to ___________________ (condition) development.
peptic ulcer
Terminal 5 amino acids of these are essential
Gastrin and CCK
Terminal 4 amino acids are essential
Gastrin’s (functional) activity
All of the amino acids here are essential
Secretin
Terminal eight amino acids are essential
CCK activity