Esophageal and Gastric secretion Flashcards
Classify the secretion of the esophagus
Only mucus secretion
These lines the main body of the esophagus
Simple mucus glands
These lines the distal esophagus, particularly at the gastric ends and initial upper portion
compound mucous glands
The function of the upper esophagus mucus gland
prevent mucosal excoriation from newly digested food
The function of the mucus gland near the Esophagogastric junction
protection against reflux
Apart from mucus, there are 2 other important gastric glands. What are those?
- Oxyntic
- Pyloric
Where are oxyntic glands found?
Fundus and body
Where are pyloric glands found?
Antrum and pylorus
What do Oxyntic glands secrete?
- HCl & Intrinsic factor from parietal cells
- Pepsinogen & lipase from peptic/chief cells
- Mucus from mucous neck cells
- Histamine from ECL cells
What do pyloric glands secrete?
- Gastrin from G cells
- Pepsinogen (small amounts)
- mucus from mucous neck cells
Where is HCl formed?
At villus-like projection in canaliculi at the secretory end of the cell
When parietal cells are stimulated, what do they secrete? What is the pH of this?
Acid solution with about 160 mmol/L HCl acid.
This acid is nearly isotonic with other bodily fluids.
This acid is extremely acidic at a pH of 0.8.
At a pH of 0.8 HCl, what is the hydrogen ion concentration?
3 million times that of the arterial blood
How many calories of energy per liter of gastric juice is required at pH 0.8?
> 1500 calories/L of gastric juice
With the hydrogen secretion, how does venous blood gain a higher pH than arterial blood during gastric acid secretion?
Bicarbonate diffuses to venous blood hence a higher pH.
