Pharmokinetics

Question 1

Absorption

Answer 1

Site of administration to systemic circulation

Question 2

Weak acid

Answer 2

Nonionized - crosses membrane
Ionized - cleared

Question 3

Weak base

Answer 3

Nonionized - cross membrane
Ionized - cleared

Question 4

pKa > pH

Answer 4

Ionized base
Unionized acid

Question 5

pKa < pH

Answer 5

Unionized base
Ionized acid

Question 6

%F

Answer 6

Bioavailability

Question 7

AUC

Answer 7

Extending of drug absorption and exposure of time

Question 8

Distribution

Answer 8

Movement from blood to tissue

Question 9

Vd

Answer 9

Volume of body fluid drug appears to distribute to
Constant for a drug
Affect by plasma binding protein
Lower Vd - stays in blood, higher Vd - move to tissue

Question 10

Metabolism

Answer 10

Biotransformation
Make more water soluble

Question 11

Elimination

Answer 11

Removing drug and metabolites

Question 12

1st order

Answer 12

Constant fraction eliminated

Question 13

K

Answer 13

Increased, increased elimination

Question 14

1/2 life

Answer 14

Time for concentration to be cut half
After 5 half lives, 95% of drug cleared

Question 15

Clearance

Answer 15

Vol/time

Question 16

Zero-order

Answer 16

RARE, linear decrease