Immune Cells

Question 1

Neutrophils

Answer 1

Found in blood
Phagocytosis, intracellular killing

Question 2

Macrophages

Answer 2

Found in tissue
Phagocytosis, intracellular killing, extracellular killing of cancer, APC

Question 3

Dendritic cells

Answer 3

APC, activate T cell

Question 4

NK cells

Answer 4

Killing of virus infected cells, cancer cells

Question 5

Mast cells

Answer 5

FAST response to allergic reaction

Question 6

Eosinophil

Answer 6

Killing of antibody coated parasites

Question 7

Basophils

Answer 7

Allergy and antiparasite immunity

Question 8

B cells

Answer 8

produce Ab
- susceptible to extracellular infections

Question 9

Th1 CD4+ cell

Answer 9

Activated infected macrophages
- susceptible to intracellular & viral infections

Question 10

Th2 CD4+ cell

Answer 10

Help with class switching
- B cells can’t produce all Ab

Question 11

Th17 CD4+ cell

Answer 11

Enhanced neutrophil response
- susceptible to fungal infections

Question 12

Treg CD4+ cell

Answer 12

Immune tolerance
- autoimmune disease

Question 13

CD8+ cell

Answer 13

Kill virus infected cells
- susceptible to viral infections

Question 14

LFA-1

Answer 14

Integrin
Expressed on T, B, NK and macrophages
Binds to I-CAM1 on APC to activate T cell, also for extravasation

Question 15

L-selectin

Answer 15

Expressed on lymphocytes
Important for homing, rolling adhesion
Binds to P-selectins on endothelial cells

Question 16

VLA-4

Answer 16

Integrin
Expressed on T, B, eosinophils
Binds to VCAM-1 on endothelial cells
Allows for extravasation into cell

Question 17

S-leX

Answer 17

Form of sialic acid expressed on a variety of leukocytes
Binds to selectins, promotes rolling adhesion

Question 18

ICAM-1

Answer 18

Expressed on effector T cells to home

Question 19

VCAM-4

Answer 19

Expressed on effector T cells to home

Question 20

PMN

Answer 20

Mostly neutrophils

Question 21

CD4+ cell

Answer 21

Important for viral infections, class switching