Pharmocology Flashcards
what is the first drug mechanism of action (sy)
synthesis:
a drug can act as precursor to increase NT effect.
or
it can inhibit enzymes to decrease NT effect.
what is the second drug mechanism of action (st)
Storage:
A drug can block a transporter to decrease NT in vesicle and stop its release.
what is the third drug mechanism of action (re)
Release:
a drug can act as docking protein in vesicle to increase NT
or
it can block the docking protein to decrease NT
what is the fourth drug mechanism of action (rec)
Receptor interaction:
Drugs can bind to receptors to either increase or decrease the NT effect.
what is the fifth drug mechanism of action (in)
Inactivation
drug can stop enzymes in the synaptic cleft to increase NT.
what is the drug mechanism of action (reu)
Reuptake
drug can block reuptake transporter to increase NT
what is the seventh drug mechanism of action
Degradation
a drug can stop the enzymes in the cell from degrading NT so agonist.
What is pharmokinetics (4 steps)
Absorption:
by bloodstream (indirect, slow by lipid soluble)
or
directly to the brain (fast)
Distribution:
the journey of the drug in the system through various tissues
Metabolism
7 mechanism / sites
Excretion.
enzymes
urine, feces, sweat, exhale, breast milk