pharmacology: side effects Flashcards

1
Q

coronary vasospasm

A

cocaine, sumatriptan, ergot alkaloids

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2
Q

cutaneous flushing

A

vancomycin, adenosine, nicacin, Ca channel blockers, echinocandina

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3
Q

dilated cardiomyopathy

A

anthracyclines (doxorubicin, daunorubicin)

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4
Q

torsades de pointes

A

antiarrhthmics (IA, III), antibiotics (macrolides), antipsychotics (haloperidol), antidepressants (TCAs), antiemetics (ondansetron)

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5
Q

adrenocortical insufficiency

A

HPA suppression secondary to glucocorticoid withdrawal

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6
Q

hot flashes

A

tamoxifen and clomiphene

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7
Q

hyperglycemia

A

tacrolimus, protease inhibitors, niacin, HCTZ, corticosteroids

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8
Q

hypothyroidism

A

lithium, amiodarone, sulfonamides

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9
Q

gynecomastia

A

spironolactone, digoxin, estrogens, cimetidine, chronic alcohol, ketoconazole, marijuana

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10
Q

acute cholestatic hepatitis, jaundice

A

erythromycin

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11
Q

diarrhea

A

acamprosate, acarbose, cholinesterase inhibitors, colchicine, erythromycin, ezetimibe, metformin, misoprostol, orlistat, pramlintide, quinidine, SSRIs

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12
Q

focal to massive hepatic necrosis

A

halothane, amanita phalloides (death cap mushroom), valproic acid, acetaminophen

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13
Q

hepatitis

A

rifampin, isoniazid, pyrazinamide, statins, fibrates

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14
Q

pancreatitis

A

didanosine, corticosteroids, alcohol, valproic acid, azathioprine, diuretics (furosemide, HCTZ)

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15
Q

pill-induced esophagitis

A

tetracyclines, bisphosphonates, potassium chloride

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16
Q

pseudomembranous colitis

A

clindamycin, ampicillin, cephalosporins

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17
Q

agranulocytosis

A

clozapine, carbamazepine, propylthiouracil, methimazole, colchicine, ganciclovir

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18
Q

aplastic anemia

A

carbamazepine, methimazole, NSAIDs, benzene, chloramphenicol propylthiouracil

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19
Q

direct coombs-positive hemolytic anemia

A

methyldopa, penicillin

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20
Q

gray baby syndrome

A

chloramphenicol

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21
Q

hemolysis in G6PD deficiency

A

isoniazid, sulfonamides, depsone, primaquine, aspirin, ibuprofen,, nitrofurantoin

22
Q

megaloblastic anemia

A

phenytoin, methotrexate, sulfa drugs

23
Q

thrombocytopenia

A

heparin

24
Q

thrombotic complications

A

OCPs, hormone replacement therapy

25
Q

fat redistribution

A

protease inhibitors, glucocorticoids

26
Q

gingival hyperplasia

A

phenytoin, Ca channel blockers, cyclosporine

27
Q

hyperuricemia (gout)

A

pyrazinamide, thiazides, furosemide, niacin, cyclosporine

28
Q

myopathy

A

fibrates, niacin, colchicine, hydroxycholoroquine, interferon-alpha, penicillamine, statins, glucocorticoids

29
Q

osteoporosis

A

corticosteroids, heparin

30
Q

photosensitivity

A

sulfonamides, amiodarone, tetracyclines, 5-FU

31
Q

rash (SJS)

A

anti-eplileptics (esp lamotrigine), allopurinol, sulfa drugs, penicillin

32
Q

SLE-like syndrome

A

sulfa drugs, hydralazine, isoniazid, procainamide, phenytoin, etanercept

33
Q

teeth discoloration

A

tetracyclines

34
Q

tendonitis/cartilage damage

A

fluoroquinolones

35
Q

cinchonism

A

quinidine, quinine

36
Q

parkinson-like syndrome

A

antipsychotics, reserpine, metoclopramide

37
Q

seizures

A

isoniazid (vit B6 deficiency) cupropion, imipenem/cilastatin, tramadol, enflurane

38
Q

tardive dyskinesia

A

antipsychotics, metoclopramide

39
Q

diabetes insipidus

A

lithiu, demeclocycline

40
Q

fanconi syndrome

A

tenofovir, ifosfamide

41
Q

hemorrhage cystitis

A

cyclophosphamide, ifosfamide

42
Q

internstitial nephritis

A

methicillin, NSAIDs, furosemide

43
Q

SIADH

A

carbamazepine, cyclophosphamide, SSRIs

44
Q

dry cough

A

ACE inhibitors

45
Q

pulmonary fibrosis

A

methotrexate, nitrofurantoin, carmustine, bleomycin, busulfan, amiodarone

46
Q

antimuscarinic

A

atropine, TCAs, H1 blockers, antipsychotics

47
Q

disulfiram-like reaction

A

metronidazole, certain cephalosporins, griseofulvin, procarbazine, 1st generation sulfonureas

48
Q

nephrotoxicity/ototoxicity

A

aminoglycosides, vancomycin, loop diuretics, cisplatin

49
Q

cytochrome P-450 inducers

A
Guinness, Corona, and PBRS induce chronic alcoholism
Griseofulvin
Carbamazepine
Phenytoin
B
Rifampin
St John's wort
50
Q

cytochrome P-450 substrates

A

anti-epileptics, theophylline, warfarin, OCPs

51
Q

cytochrome P-450 inhibitors

A
AAA RACKS In GQ Magazine
Acute Alcohol Abuse
Ritonavira
Amiodarone
Cimetidine/ciprofloxacin
Ketoconazole
Sulfonamide
Isoniazid
Grapefruit juice
Quinidine
Macrolides (except azithromycin)