Pharmacology Questions

Question 1

Amioderone

Class?
What is used to treat? (4)
Side effects? (7)

Answer 1

Class
- class III antiarrhythmic
What is used to treat?

• VT, AF, VFib, Paroxysmal supraventricular tachy

Side effects?
- Nausea
- Constipation
- Lethargy
- Tremor
- Interstitial pneumonitis
- Optic neuropathy
- corneal deposits

Question 2

Amioderone

Why can it cuase toxicity in other drugs the patient is taken?

4/7 Drugs that it can affect

Answer 2

Amiodarone inhibits the action of cytochrome P450 enzyme, clearance of many drugs may be reduced.

This includes:
Ciclosporin
Digoxin
Flecainide
Sildenafil
Simvastatin
Theophylline
Warfarin

Question 3

What class of drug used for hayfever?

Answer 3

Histamine-1 antagonist

Question 4

What are Histamine 2 antagonist used for and an eg?

Answer 4

Antacids eg. ranitidine

Question 5

Cocaine
Mech of action?

Answer 5

MOA: cocaine blocks the uptake of dopamine, noradrenaline and serotonin

Question 6

Management of cocaine toxicity

1) first line
2) If chest pain
3) If induces HTN

Answer 6

1) Benzos
2) Chest pain= Benzo + GTN if MI then PCI
3) Benzo + sodium nitroprusside