Pharmacology of the nervous system Flashcards

1
Q

Define pharmacology

A

A chemical substance that interacts with a specific trader within a biological system to produce a physiologic effect

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2
Q

What questions should be asked concerning drugs?

A

What is the response produced?
What is the target for the drug?
Where is the effect produced?

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3
Q

Why do people take heroine?

A

Euphoria
Analgesia
Cough-surpression

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4
Q

Where are the effects of heroine produced?

A

Three areas of the brain

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5
Q

What is the target for heroine?

A

Opioid receptors in the brain

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6
Q

What are the 4 main classes of drug targets?

A

Receptors
Enzymes
Transport proteins
Ion channels

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7
Q

What does atorvastatin target?

A

Enzyme

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8
Q

What does amlodipine target?

A

Ion channel

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9
Q

What does salbutamol target?

A

Receptor

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10
Q

What does citalopram target?

A

Transport protein

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11
Q

What are the two main ways by which drugs act?

A

Enhance activation

Prevent activation

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12
Q

What must a drug be to be effective?

A

Must show high degree of selectivity for a particular target

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13
Q

Whys is high selectivity more important for drugs that are endogenous compounds like dopamine?

A

Method of delivery is difficult
In body, compound is delivered directly to the target
But the drug can bind to different targets in multiple places meant for different compounds
Since delivery is widespread

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14
Q

What are side effects?

A

Effect produces by the drug that is secondary to the intended effect

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15
Q

What is an adverse effect?

A

A side effect that has negative health consequences

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16
Q

What drug is used to treat Parkinson’s?

A

Pramipexole- a dopamine receptor agonist

17
Q

What can cause side effects?

A

Effects on same target (same or different tissues)

Effects of different targets (same or different tissues)

18
Q

What are side effects dependent on?

A

Dosage

19
Q

What are the ‘safest’ drugs?

A

Large difference between dose required to induce the desired effects and the dose required to induce side effects