Pharmacology - more anti-cancer

Question 0

Which SERM does not increase the risk of endometrial cancer?

Answer 0

Raloxifene

Question 1

Common chemotoxicities of Chemo-Tox Man.

Answer 1

Cisplatin/carboplatin - acoustic nerve damage, nephrotoxicity
Bleomycin - pulmonary fibrosis
Doxorubicin - cardiotoxicity
CYclophosphamide - hemorrhagic cystitis
5-FU, 6-MP, and MTX - myelosuppression

Question 2

What is the mechanism of action of cisplatin and carboplatin?

Answer 2

Cross-link DNA.

Question 3

How do you prevent nephrotoxicity with cisplatin/carboplatin?

Answer 3

give amifostone (free radical scavenger) and chloride diuresis

Question 4

What is the mech of hydroxyurea?

Answer 4

inhibits ribonucleotide reductase

Question 5

What kind of drug is cyclophosphamide?

Answer 5

alkylating agent

Question 6

What is the mech of cyclophosphamide and ifosfamide?

Answer 6

Covalently cross-link DNA at N-7 guanine. Require activation in the liver.

Question 7

Which alkylating agents are used for CNS tumors?

Answer 7

Nitrosureas

Question 8

Name the nitrosureas.

Answer 8

carmustine and the other “-ustines”, streptozocin

Question 9

What is the mechanism of action of busulfan?

Answer 9

alkylates DNA

Question 10

Alkaloids that bind to tubulin and prevent the formation of the mitotic spindle.

Answer 10

Vinblastine and vincristine.

inhibit microtubules, the vines of our cells

Question 11

Mech of pacliTAXel and other TAXols.

Answer 11

Hyperstabilize microtubules so that mitotic spindles cannot break down.