Misc

Question 1

What hormone regulates iron absorption and release into the bloodstream? Where is it produced?

Answer 1

Hepcidin from hepatocytes.

Question 2

What specific processes does hepcidin regulate?

Answer 2

Absorption of Fe in intestinal epithelial cells, how much absrbed iron goes into bloodstream an how much into ferritin, and release of Fe from macrophages of the reticuloendothelial system.

Question 3

3 predisposing factors to sickling in sickle cell patients.

Answer 3

Low O2
acidity
low blood volume

Question 4

What is the effect of nitrite poisoning?

Answer 4

Methemoglobinemia

Question 5

Of which isotype are the anti-A or anti-B Abs in people w/ B or A blood types?

Answer 5

IgM

Question 6

Of which isotype are the anti-A and anti-B Abs in people w/ AB blood type?

Answer 6

IgG

Question 7

Isotype of anti-Rh Igs?

Answer 7

IgG

Question 8

Hemolytic anemia w/ bite cells and Heinz bodies after dapsone or TMX-SMP.

Answer 8

G6PD deficiency anemia

Question 9

What is Odansetron and what is its primary clinical use?

Answer 9

5-HT3 receptor antagonist. Tx of nausea and vomiting caused by chemotherapy.

Question 10

What is the primary defect in hereditary spherocytosis?

Answer 10

Spectrin and/or ankyrin, cytoskeletal proteins are deficient and PM blebs off.

Question 11

What kind of anemia does hereditary spherocytosis cause?

Answer 11

hemolytic anemia

Question 12

Where are blood cells destroyed in hereditary spherocytosis?

Answer 12

in the spleen

Question 13

Why is MCHC elevated in hereditary spherocytosis?

Answer 13

Red cell volume is depleted as PM and cytoplasm bleb off.