Pharmacology - cancer Flashcards
1
Q
Mech of dactinomycin
A
Intercalates in DNA
2
Q
Uses of dACTinomycin
A
Wilms’ tumor and Ewing’s sarcoma
Children ACT out.
3
Q
Mech of doxorubicin.
A
Non-covalently intercalates in DNA, causing breaks.
4
Q
What can you give to prevent cardiotoxicity from doxo-/daunorubicin?
A
Dexrazoxane, an iron chelating agent.
5
Q
Inhibits topoisomerase II and causes DNA degradation.
A
etoposide (VP-16) and teniposide
6
Q
Monoclonal Ab against CD20
A
Rituximab
7
Q
Clinical uses of rituximab
A
NHL, RA
8
Q
Monoclonal Ab against Her-2 (erb-B2)
A
Trastuzumab (herceptin)
9
Q
Monoclonal Ab against bcr-abl Tyr kinase.
A
Imatinib (Gleevec)
10
Q
What is the mechanism of cardiotoxicity with doxorubicin?
A
Interaction with iron generates free radicals.
