Oncology

Question 1

Smudge cells in peripheral blood smear.

Answer 1

Small Lymphocytic Lymphoma (SLL) / Chronic Lymphocytic Leukemia (CLL)

Question 2

Stain used for Hairy cell leukemia.

Answer 2

TRAP (tartrate-resistant acid phosphatase)

Question 3

Which AML subtype responds to all-trans retinoic acid?

Answer 3

M3 AML (t15;17) - induces differentiation of myeloblasts.

Question 4

Monoclonal antibody for treating CML. How does it work?

Answer 4

Imatinib targets the bcr-abl Tyr kinase and inhibits it.

Question 5

Auer rods? What is the result of their release?

Answer 5

Seen within myeloblasts in M3 AML. Release instigates DIC.

Question 6

Describe Auer rods.

Answer 6

Peroxidase-(+) cytoplasmic inclusions in granulocytes and myeloblasts

Question 7

May transform into AML or ALL in a “blast crisis”.

Answer 7

CML

Question 8

Increased NΦ, metamyelocytes, and basophils; very low leukocyte ALP.

Answer 8

CML (low leukocyte ALP indicates immature leukocytes. therefore, not leukemoid reaction, which has mature leukocytes.)

Question 9

Typical age for acute lymphoblastic leukemia/lymphoma.

Answer 9

<15 y.o.

Question 10

Smudge cells.

Answer 10

SLL / CLL

Question 11

Pt. over 60. Asymptomatic. Warm Ab immune hemolytic anemia.

Answer 11

SLL / CLL

Question 12

Bone marrow replaced by lymphoblasts. TdT(+) and CALLA(+)

Answer 12

ALL

Question 13

Mediastinal mass in an adolescent male.

Answer 13

ALL

Question 14

Tennis-racket shaped granules. Expresses S-100 and CD1a.

Answer 14

Langerhans cell histiocytosis (LCH)

Question 15

What are the markers of the neoplastic dendtritic cells in LCH?

Answer 15

S-100 and CD1-a