Pathology 1

Question 1

What are the causes of megaloblastic anemia?

Answer 1

Folate or B12 deficiency or orotic aciduria due to UMPS deficiency.

Question 2

How can you differentiate the orotic aciduria of UMPS deficiency from that of OTC deficiency?

Answer 2

Decreased BUN in OTC deficiency due to impaired urea cycle. Also no megaloblastic anemia in OTC deficiency.

Question 3

How would you differentiate folate from B12 deficiency CLINICALLY?

Answer 3

Peripheral neuropathy in B12 deficient pts. (d/t role of B12 in fatty acid pathways.)

Question 4

How would lab tests differ in folate- and B12-deficiency?

Answer 4

Methylmalonic acid increased in B12 deficiency.

Question 5

Causes of DIC

Answer 5

STOP Making New Thrombi
Sepsis
Trauma
Obstetric complications
Pancreatitis
Malignancy
Nephrotic syndrome
Transfusion

Question 6

Indications for fresh frozen plasma.

Answer 6

DIC, cirrhosis, warfarin over-anticoagulation

Question 7

What is the classic triad of Wiskott-Aldrich syndrome?

Answer 7

eczema, thrombocytopenia, and combined B- and T-lymphocyte deficiency.