Pharmacology in Kidney disease/AKI Flashcards
1
Q
Drugs to avoid in renal failure
A
Antibiotics: Tetracycline, nitrofurantoin
NSAIDs
Lithium
Metformin
2
Q
Drugs likely to accumulate in chronic kidney disease - need dose adjustment
A
Most antibiotics including penicillins, cephalosporins, vancomycin, gentamicin, streptomycin
digoxin, atenolol
Methotrexate
Sulphonylureas
Furosemide
Opioids
3
Q
Should be stopped in AKI as may worsen renal function
A
- NSAIDs (except if aspirin at cardiac dose e.g. 75mg od)
- Aminoglycosides
- ACE inhibitors
- Angiotensin II receptor antagonists
- Diuretics
4
Q
May have to be stopped in AKI as increased risk of toxicity (but doesn’t usually worsen AKI itself)
A
- Metformin
- Lithium
- Digoxin
