Antidepressants Flashcards
Setraline/citalopram/fluoxetine
- Class
- MoA
- Indications
- Side effects
- Pregnancy
- Interactions
- Extra info
Class:
Selective serotonin reuptake inhibitor
MoA:
Inhibition of serotonin reuptake in synapses
Indications:
Depression, OCD, GAD, PTSD
Side effects:
GI effects, hyponatremia, sexual dysfunction, suicidal thoughts, serotonin syndrome, long QT syndrome (citalopram)
Pregnancy rules:
Can increase risk of pulmonary hypertension, fluoxetine avoided in breastfeeding
Interactions:
NSAIDs, triptans, warfarin
Extra info:
Setraline best in post MI
Mirtazapine
- Class
- MoA
- Side effects
Class:
Noradrenergic and specific serotonergic antidepressant (NaSSA)
MoA:
Antagonises alpha-2 receptors causing serotonin/noradrenaline release. Antagonises 5HT2 receptor leaving 5HT1 unopposed.
Side effects:
Weight gain, sedation
Amitriptyline
- Class
- MoA
- Indications
- Side effects
Class:
Tricyclic antidepressant
MoA:
Blocks the reuptake of serotonin and noradrenaline. Added anti muscarinic, anti histamine and anti adrenergic effects.
Indications:
Depression, neuropathic pain
Side effects:
Urinary retention, drowsiness, blurred vision,** constipation**, dry mouth, long QT syndrome, postural hypotension
