Pharmacology- First Aid

Question 1

Drug Reactions- Coronary vasospasm

Answer 1

cocaine, sumatriptan, ergot alkaloids

Question 2

Drug Reactions- Cutaneous flushing

Answer 2

vancomycin, adenosine, niacin, Ca channel blockers

Question 3

Drug Reactions- dilated cardiomyopathy

Answer 3

doxorubicin, daunorubicin

Question 4

Drug Reactions- torsades de pointes

Answer 4

Class III and Ia antiarrhythmics, macrolides, antipsychotics, TCA’s

Question 5

Drug Reactions- hot flashes

Answer 5

tamoxifen, clomiphene

Question 6

Drug Reactions- hyperglycemia

Answer 6

tacrolimus, protease inhibitors, niacin, HCTZ, beta blockers, corticosteroids

Question 7

Drug Reactions- hypothyroidism

Answer 7

lithium, amiodarone, sulfonamides

Question 8

Drug Reactions- acute cholestatic hepatitis, jaundice

Answer 8

erythromycin

Question 9

Drug Reactions- diarrhea

Answer 9

metformin, erythromycin, colchicine, orlistat, acarbose

Question 10

Drug Reactions- focal to massive hepatic necrosis

Answer 10

halothane, amanita phalloides, valproic acid, acetaminophen

Question 11

Drug Reactions- hepatitis

Answer 11

INH (isoniazid)

Question 12

Drug Reactions- pancreatitis

Answer 12

didanosine, corticosteroids, alcohol, valproic acid, azathioprine, diuretics

Question 13

Drug Reactions- pseudomembranous colitis

Answer 13

clindamycin, ampicillin, cephalosporins

Question 14

Drug Reactions- agranulocytosis

Answer 14

dapsone, clozapine, carbamazepine, colchicine, methimazole, propylthiouracil

Question 15

Drug Reactions- aplastic anemia

Answer 15

carbamazepine, methimazole, NSAIDS, benzene, chloramphenicol, PTU

Question 16

Drug Reactions- direct coombs (positive hemolytic anemia)

Answer 16

methyldopa, penicillin

Question 17

Drug Reactions- gray baby syndrome

Answer 17

chloramphenicol

Question 18

Drug Reactions- hemolysis in G6PD deficiency

Answer 18

INH, sulfonamids, dapsone, primaquine, aspirin, ibuprofen, nitrofuratoin

Question 19

Drug Reactions- megaloblastic anemia

Answer 19

phenytoin, methotrexate, sulfa drugs

Question 20

Drug Reactions- thrombocytopenia

Answer 20

heparin, cimetidine

Question 21

Drug Reactions- thrombotic complications

Answer 21

OCP’s

Question 22

Drug Reactions- fat redistribution

Answer 22

protease inhibitors, glucocorticoids

Question 23

Drug Reactions- gingival hyperplasia

Answer 23

phenytoin, verapamil, cyclosporine, nifedipine

Question 24

Drug Reactions- gout

Answer 24

pyrazinamid, thiazides, furosemide, niacin, cyclosporine

Question 25

Drug Reactions- myopathy

Answer 25

fibrates, niaicin, colchicine, hydroxychloroquine, interferon-alpha, penicillamine, statins, glucocorticoids

Question 26

Drug Reactions- osteoporosis

Answer 26

corticosteroids, heparin

Question 27

Drug Reactions- photosensitivity

Answer 27

sulfonamides, amiodarone, tetracyclines, 5-FU

Question 28

Drug Reactions- steven johnson’s

Answer 28

anti-epileptic drugs, allopurinol, sulfa drugs, penicillin

Question 29

Drug Reactions- SLE like

Answer 29

sulfa drugs, hydralazine, INH, procainamide, phenytoin, etanercept

Question 30

Drug Reactions- teeth discoloration

Answer 30

tetracycline

Question 31

Drug Reactions- tendon rupture

Answer 31

fluoroquinolones

Question 32

Drug Reactions- cinchonism

Answer 32

quinidine, quinine

Question 33

Drug Reactions- parkinson-like

Answer 33

antipsychotics, reserpine, metoclopramide

Question 34

Drug Reactions- seizures

Answer 34

INH, bupropion, imipenem/cilastatin, tramadol, enflurane, metoclopramide

Question 35

Drug Reactions- tardive dyskinesias

Answer 35

antipsychotics, metoclopramide

Question 36

Drug Reactions- diabetes insipidus

Answer 36

lithium, demeclocycline

Question 37

Drug Reactions- fanconi syndrome

Answer 37

expired tetracycline

Question 38

Drug Reactions- hemorrhagic cystitis

Answer 38

cyclophosphamide, ifosfamide

Question 39

Drug Reactions- interstitial nephritis

Answer 39

methicillin, NSAIDs, furosemide

Question 40

Drug Reactions- SIADH

Answer 40

carbamazepine, cyclophosphamide, SSRI’s

Question 41

Drug reactions- dry cough

Answer 41

ACE inhibitors (inhibit degradation of bradykinin which is a bronchial vasoconstrictor)

Question 42

Drug Reactions- pulmonary fibrosis

Answer 42

bleomycin, amiodarone, busulfan, methtrexate

Question 43

Drug Reactions- antimuscarinic

Answer 43

atropine, TCA’s, H1 blockers, antipsychotics

Question 44

Drug Reactions- disulfram

Answer 44

metronidazole, certain cephalosporins, griseofulvin, procarbazine, 1st generation sulfonylureas

Question 45

Drug Reactions- nephrotoxicity or ototoxicity

Answer 45

aminoglycosides, vancomycin, loop diuretics, cisplatin