Pharmacology (Day 1) Flashcards
What inhibits the synthesis of NE/Epi (aka tyrosine hydroxylase)?
Metyrosine
What inhibits/blocks VMAT-mediated storage granule (of NE)?
Reserpine
What inhibits NET (Reuptake-1) at the nerve terminal? What does this leads to?
- Cocaine, Imipramine, Atoxomoxetine
- Increased NE in the synaptic terminal
What promotes the release of NE/DA?
- Amphetamines
- Tyramine
What are some agonists of α1 receptors?
- Epi/NE
- Phenylephrine
What are some agonists of α2 receptors?
- (alpha) Methyldopa
- Clonidine
- Guanfacine
What is an agonist of β1 receptors?
Dobutamine
What is an agonist of β2 receptors?
Albuterol
What are inhibitors of MAO-A?
- Phenelzine
- Tranylcypromine
What does MAO-A metabolize?
- Epi/NE
- Seratonin (5HT)
- Dopamine
- Tyramine
What does MAO-B metabolize?
- Dopamine
- Tyramine
What are inhibitors of MAO-B?
- Selegiline
- Rasagiline
What are some COMT inhibitors of MAO-B (only 20%)?
- Tolcapone
- Entacapone
Name the drugs that act upon β2 receptors.
- Albuterol
- Salmeterol
- Terbutaline
- Ritodrine
What drug acts on β3 receptors?
Mirabegron
What is a dopamine-1 agonist?
Fenoldopam
What are the two non-selective β blockers?
- Propranolol
- Timolol
What are selective β1 blockers?
- Atenolol (β1 >β2)
- Esmolol
- Metoprolol
What are β and α1 blockers?
- Carvediol
- Labetolol
(β1 = β2)
What is used to treat hyperthyroidism and glaucoma?
Non-Selective β blockers
What is used to treat CAD, DM, and bronchial asthma?
Selective β1 blockers
What is used to treat Congestive Cardiac Failure?
β and α1 blockers
What are some negative effects on the heart from propanolol?
- Negative inotropic action (decreased speed/force)
- Negative chronotropic action (decreased HR)
- Decreased AV conduction
What are some adverse effects of beta blockers?
- AV Block and bradycardia
- Bronchial asthma and COPD
- Cold extremities
- Hyperlipidemia
- Sexual Dysfunction
