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MTM Exam 4 > Pharmacology (Day 1) > Flashcards

Pharmacology (Day 1) Flashcards

1
Q

What inhibits the synthesis of NE/Epi (aka tyrosine hydroxylase)?

A

Metyrosine

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2
Q

What inhibits/blocks VMAT-mediated storage granule (of NE)?

A

Reserpine

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3
Q

What inhibits NET (Reuptake-1) at the nerve terminal? What does this leads to?

A
  • Cocaine, Imipramine, Atoxomoxetine
  • Increased NE in the synaptic terminal
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4
Q

What promotes the release of NE/DA?

A
  • Amphetamines
  • Tyramine
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5
Q

What are some agonists of α1 receptors?

A
  • Epi/NE
  • Phenylephrine
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6
Q

What are some agonists of α2 receptors?

A
  • (alpha) Methyldopa
  • Clonidine
  • Guanfacine
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7
Q

What is an agonist of β1 receptors?

A

Dobutamine

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8
Q

What is an agonist of β2 receptors?

A

Albuterol

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9
Q

What are inhibitors of MAO-A?

A
  • Phenelzine
  • Tranylcypromine
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10
Q

What does MAO-A metabolize?

A
  • Epi/NE
  • Seratonin (5HT)
  • Dopamine
  • Tyramine
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11
Q

What does MAO-B metabolize?

A
  • Dopamine
  • Tyramine
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12
Q

What are inhibitors of MAO-B?

A
  • Selegiline
  • Rasagiline
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13
Q

What are some COMT inhibitors of MAO-B (only 20%)?

A
  • Tolcapone
  • Entacapone
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14
Q

Name the drugs that act upon β2 receptors.

A
  • Albuterol
  • Salmeterol
  • Terbutaline
  • Ritodrine
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15
Q

What drug acts on β3 receptors?

A

Mirabegron

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16
Q

What is a dopamine-1 agonist?

A

Fenoldopam

17
Q

What are the two non-selective β blockers?

A
  • Propranolol
  • Timolol
18
Q

What are selective β1 blockers?

A
  • Atenolol (β1 >β2)
  • Esmolol
  • Metoprolol
19
Q

What are β and α1 blockers?

A
  • Carvediol
  • Labetolol

(β1 = β2)

20
Q

What is used to treat hyperthyroidism and glaucoma?

A

Non-Selective β blockers

21
Q

What is used to treat CAD, DM, and bronchial asthma?

A

Selective β1 blockers

22
Q

What is used to treat Congestive Cardiac Failure?

A

β and α1 blockers

23
Q

What are some negative effects on the heart from propanolol?

A
  • Negative inotropic action (decreased speed/force)
  • Negative chronotropic action (decreased HR)
  • Decreased AV conduction
24
Q

What are some adverse effects of beta blockers?

A
  • AV Block and bradycardia
  • Bronchial asthma and COPD
  • Cold extremities
  • Hyperlipidemia
  • Sexual Dysfunction

MTM Exam 4 (12 decks)

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