Pharmacology COPY Flashcards
1 allergic reaction
NMBDs
Myasthenia gravis
Resistance to SUX
(My Grave has Rusting Socks)
More sensitive to ND-NMBDs (My Great Senses Roc- more sensitive to roc).
Myasthenic syndrome is sensitive to both
LEMS
MORE sensitive to BOTH
Side effects of Terbutaline
hypoK, hypotension
MI, pulmonary edema
hypERglycemia
Drugs that DO NOT cross the placenta
tHINGS:
heparin
insulin
ND-NMBDs
Glyco
SUX
Level of Mag with loss of DTRs
10-12
Goal = 4-8
Res paralysis = 15
Cardiac arrest = 25
Tx = Ca
NMDA & L-type Ca channels
Mechanism of Milrinone
Dec hydrolysis of cAMP –> inc ionotropy
Pulmonary vasodilator
Inhibitors of CYP1A2
Fluoroquinolones
Fluvoxamine
Verapamil
Avoid using Tizanidine with these
Drugs with inc [plasma] in ESLD
Thiopental
Benzos
Alfentanil
[Bad livers can’t metabolize BATs]
Sodium nitroprusside
Cyanide toxicity - >1mg/kg in 2 hours
Signs - inc MvO2, acidosis
Thiocyanate toxicity - long term SNP or renal failure
Signs - N/V, seizure, spasms
Inc cGMP
May induce coronary steal/reduce CPP
Phenytoin MOA
Blocks Na channels - shortens ventricular depolarization
Gingival hyperplasia
Initially enhances ND-NMBD then resistance with chronic use
Antibiotic that cover both MRSA and gram-negative
Tigecycline
Drugs dosed on total body weight
Sux -
Drugs dosed on lean body weight
opioids
induction meds
Drugs dosed on ideal body weight
ND-NMBDs
Allergy to amioamides cause
Methylparaben
With epi = metabisulfite
Pain drugs that lower seizure threshold
Tramadol
TCAs (amytriptyline)
NMBD with highly active metabolite
Vecuronium - 3-desacetyl
Dose of ropivicaine for caudal to cover low thoracic dermatomes (inguinal hernia)
1ml/kg
Sarin gas attack (sxs & rx)
Sx - salivation, lacrimation, urination, diaphoresis, vomiting, bronchospasm, blurred vision (excess Ach from ACH-esterase inhibitor)
Tx = atropine + pralidoxime
Mechanism of Amicar and TXA
competitive inhibition of plasmin
Mechanism of sulfur mustard agent
blistering vesicant - attacks DNA, RNA and cell membranes
Fenoldopam mech
D1 agonist
Mechanism of plavix and ticlopidine
ADP receptor inhibition
Mechanism of abciximab, tirofiban
GP IIb/IIIa inhibition
NMBD dosing after burns
Increase
Maximum tumescent lidocaine
55mg/kg
Mech of Mag interaction w/ NMBDs
Competes with Ca
Inc sensitivity to both NMBDs
Amount of epi in 1:200,000
5mcg/ml
Med interactions with fluoxetine
Inc [plasma] of BBs, antiarrythmics, TCAs
[the BAT flu(flew) over the ox.]
Drug approved for HIT
Argatroban
Drugs removed/metabolized by the lungs
Local
Opioids
Propofol, ketamine
NE, dopamine
NOT metabolized = NMBDs, Epi
Effect of SNP A118G response to morphine
Inc requirement
Herbal medicine that decreases therapeutic level of warfarin
St Johns Wort
Electrolyte changes with acetazolamide
hyperchloremic metabolic acidosis
Dec Na
Dec Bicarb
