Pharmacology - Antidepressants Flashcards
what types of drugs can most effectively cross the blood brain barrier?
hydrophobic/lipophillic
what antidepressant should be avoided in people with ischaemic heart disease?
imipramine
it is cardiotoxic in high doses
what mood stabilising drug needs to have therapeutic drug monitoring?
lithium
how is lithium metabolised?
it ISNT.
it is an element so is not metabolised
what is the effect of dehydration on lithium levels?
increases lithium levels
which mood stabiliser needs to be avoided in people who plan to get pregnant soon?
valproic acid
teratogenic
what are the three main classes of antidepressant drugs?
monoamine oxidase inhibitors
monoamine reuptake inhibitors
atypical drugs
what are the four types of monoamine reuptake inhibitors?
tricyclics
other non selective reuptake inhibitors
SSRI’s
noradrenaline reuptake inhibitors
what are the three monoamine neurotransmitters?
dopamine
noradrenaline
5-HT
what is another name for 5-HT?
serotonin
name two monoamine oxidase inhibitors
phenelzine
moclobemide
what neurotransmitters are affected by monoamine oxidase inhibitors?
all monoamine neurotransmitters - not selective
what is the mode of action of monoamine oxidase inhibitors?
inhibitors of MOA
can be reversible or irreversible
which monoamine oxidase inhibitor is reversible?
moclobemide
phenelzine is irreversible
what is a very serious potential side effect of monoamine oxidase inhibitors?
hypertensive crisis
name three potential side effects of monoamine oxidase inhibitors
insomnia
postural hypotension
peripheral oedema
name a tricyclic antidepressant
imipramine
what is the mode of action of tricyclic antidepressants?
block the reuptake of monoamines into presynaptic terminals