Neurobiology - Addiction Flashcards
1
Q
what six things make up the criteria for dependence?
A
strong desire to take the substance difficulties controlling use physiological withdrawal state tolerance neglect of alternative pleasures persistence despite evidence of harm
2
Q
when is dependence diagnosed?
A
when three or more criteria have been present at the same time in the last year
3
Q
what questionnaire is used to assess alcohol dependence?
A
CAGE
4
Q
what questions make up the CAGE questionnaire?
A
think you should CUT DOWN?
have people ANNOYED you by criticising your drinking?
ever feel GUILTY about drinking?
ever had an EYE OPENER to steady nerves in the morning?
5
Q
what neural pathway is involved in addiction?
A
the mesolimbic pathway
6
Q
what mediates the activity of the mesolimbic pathway?
A
dopamine
7
Q
what receptors are decreased in addiction?
A
dopamine D2 receptors
8
Q
what part of the brain is responsible for preventing addiction in the vast majority of people?
A
the pre-frontal cortex
