Pharmacology - Antiarrthmics

Question 1

Which of the following describe action potential?
Select ALL that apply.

Answer 1

Voltage change in action potential is described as polarized and depolarized state

Question 2

Which of the following describe the mechanism of action for Class Ia antiarrhythmics?

Answer 2

Moderate sodium channel blockade with some potassium channel blockade leading to prolongation of the action potential duration

Question 3

Class I antiarrhythmics not only have class specific adverse effects but agent specific adverse effects as well. True or False?

Answer 3

true

Question 4

Which of the following Class I antiarrhythmic agents has CNS toxicity effects?

Answer 4

Lidocaine

Question 5

Class III antiarrhythmics mainly act on potassium channels. Potassium ion movement out of the cell governs which of the following?

Answer 5

action potential duration

Question 6

Which of the following is the main adverse effect of Potassium channel blockade with Class III agents:

Answer 6

QT prolongation

Question 7

Which of the following is true regarding class II agents:
Select ALL that apply.

Answer 7

Class II agents competitively bind with beta adrenoceptor sites

Class II agents can be selective, non-selective or non-selective mixed agents

Class II agents work on the kidney to decreasing renin secretion

Question 8

Amiodarone can increase the effect of Heparin as well as the serum concentrations of Digoxin, Procainamide, and other medications. True or False?

Answer 8

False

Question 9

Class IVa agents such as Diltiazem have relatively localized nodal calcium ion channels due to:

Answer 9

Phase 0 of AV and SA node action potential is Calcium dependent

Question 10

Class IVb agents are calcium channel blockers through indirect action via:

Answer 10

Potassium ion channel opening

Question 11

Class V antiarrhythmic medications account for:

Answer 11

Medications that do not fit into the other categories