Medicatons Affecting Coagulation PART 2

Question 1

After oral administration of Asprin:

Answer 1

It is rapidly absorbed from the GI tract
Permanently inactivates COX 1 dependent TXA2 production
Peak levels occur in 30-40 minutes

Question 2

Match the following

Answer 2

Question 3

Which of the following is related in increased risk of high platelet reactivity:

Answer 3

Cardiac Surgery

Question 4

Which of the following describes Clopidogrel’s mechanism of action:

Question 5

Which of the following is true regarding the pharmacokinetics of clopidogrel:

Answer 5

Clopidogrel must be metabolized to generate its active metabolite

Question 6

Ticagrelor’s mechanism of action is related to which of the following:

Answer 6

Ticagrelor reversibly binds to P2Y12 to inhibit ADP induced platelet aggregation

Question 7

Which of the following is true regarding Ticagrelor’s pharmacokinetics:

Answer 7

Ticagrelor does not require metabolic activation