Pharmacology Flashcards
Drug reaction causing hyperprolactinemia
-Typical antipsychotics (Haloperidol)
-Atypical antipsychotics
(Quetiapine)
-Metoclopramide
-Methyldopa
Drug reaction causing SIADH
-Carbamezepine
-Cyclphosphamide
-SSRI’s
(Mnemonic: Can’t Concentrate Serum Sodium)
Drug reaction causing Acute cholestatic Hepatitis/jaundice
Macrolides (erythromycin)
Drug reaction causing Diarrhea
- Lipid lowering agents (Ezetimibe, orlistat)
- Cholinesterase inhibitors
- antidiabetics (metformin, acarbose, pramlintide)
- Quinidine
- SSRI’s
- Macrolides (erythromycin)
Drug reaction causing Hepatic necrosis
-Halothene
-Amanita Phalloides (death cap mushroom)
-Valporate
-Acetaminophen
(HAVAc)
Drug reaction causing Hepatitis
- Rifampin
- Isoniazid
- Pyrazinamide
- Statins
- Fibrates
Drug reaction causing Pill induced esophagitis
- NSAIDS
- Bisphosphonates
- Ferrous Sulfate
- Potassium Chloride
- Tetracyclines
Drug reaction causing Pancreatitis
-Didanosine
-Corticosteroids
-Alcohol
-Valproic acid
-Azathioprine
Diuretics (Furosemide, HCTZ)
Drug reaction causing Pseudomembranous colitis
- Cephalosporins
- Ampicillin
- Clindamycin
- Fluoroquinolines
Drug reaction causing Hyperglycemia
-Tacrolimus
-Protease inhibitors
-Niacin
-HCTZ
-Corticosteroids
(Mnemonic: The People Need Hard Candy)
Drug reaction causing Agranulocytosis (Severe decrease in WBCs esp neutrophils)
- Clozapine
- Carbamezapine
- Propylthiouracil
- Methimazole
- Colchicine
- Ganciclovir
(Mnemonic: Can Cause Pretty Major Collapse of Granulocytes)
Drug reaction causing Aplastic anemia
- Carbamezapine
- Methimazole
- NSAIDs
- Benzene
- Chloramphenicol
- Propylthiouracil
(Mnemonic: Can’t Make New Blood Cells Properly)
Drug reaction causing Eosinophilia and systemic symptoms (DRESS)
- Allopurinol
- Anticonvulsants
- Antibiotics
- Sulfa drugs
Tx: Stop offending drug, give corticosteroids)
Drug reaction causing Direct Coombs positive hemolytic anemia (autoimmune destruction of red blood cells)
- MethylDopa
- Cephalosporins
- Penicillin
(Mnemonic: Direct Coombs Positive)
Drug reaction causing decreased platelets
- Heparin
- Vancomycin
- Linezolid
(Mnemonic: Help, Very Low platelets)
Drug reaction causing Gingival hyperplasia
- Cyclosporine
- Ca+ channel blockers
- Phenytoin
Mnemonic: Can Cause Puffy gums
Drug reaction causing Gout/hyperuricemia
- Pyrazinamide
- Thiazides
- Furosemide
- Niacin
- Clyclosporin
Drug reaction causing myopathy
-Hydroxychoroquine
-Statins
-Niacin
-Fibrates
-Daptomycin
-Colchicine
-Penicillamine
-Interferon-A
-Glucocorticoids
(Mnemonic: stop fishy drugs causing pain in glutes
Drug reaction causing Photsensitivity
- Sulfamides
- mail adobe
- 5-FU-Tetracycline
Drug reaction causing Parkinson’s-like syndrome
- Antipsychotics
- Reserpine
- Metoclopramide
Drug reaction causing Pseudotumor cerebri
- Tetracyclines
- Vitamin A
- Growth hormones
Drug reaction causing Peripheral neuropathy
- Vincristine
- Phenytoin
Drug reaction causing Seizures
- Imipenam/Cilastatin
- Isoniazid
- Bupropion
- Tramadol
- Enflurane
(Mnemonic: with seizures I BITE my tongue)
Drug reaction causing Tardive dyskinesia
- Antipsychotics
- Metoclopramide
Drug reaction causing Visual defects
- Topiramate (blurred vision, diplopia, haloes)
- Digoxin (yellow vision)
- Isoniazid (optic neuropathy/color vision change)
- Vigabatrin (Bilateral visual field defects)
- Ethambutol (color vision changes)
- PDE-5 inhibitors like sildinafel aka viagra (blue vision) viagra blues
Drug reaction causing Hemorrhagic cystitis
- Cyclophosphamide
- Ifosfamide
Drug reaction causing Fanconi syndrome
- Cisplatin
- Ifosfamide
- expired tetracyclines (doxy, mino)
- tenofivir
Drug reaction causing Interstitial nephritis
- PPIs
- Penicillins
- furosemide
- sulfa drugs
Drug reaction causing Pulmonary fibrosis
- Methotrexate
- Nitrofurantoin
- Carmustine
- Bleomycin
- Busulfan
- Amiodarone
Drug reaction causing Antimuscularinic symptoms
-sympathetic
-cant see (dilation), cant pee (relaxes bladder) cant shit (relaxes bowel)
-drugs:
H1 blockers (loratidine)
Atropine
TCAs (tryptalines)
Antipsychotics (haloperidol)
Disulfiram like reaction (hangover)
- first generation sulfonylureas; acetohexamide)
- Metronidazole
- Cephalosporins
- Griseofulvin
- Procarbazine
mnemonic: Sorry Molly, Can’t Go Party
Drug reaction causing Nephrotoxicity/ototoxicity
- Vancomycin
- amphotericin B
- Loop diuretics
- Aminoglycosides
- cisPlatin
Very Bad Listeners And Pissers.
Sulfa drugs
- Sulfonamide antibiotics
- Sulfasalazine
- Acetazolamide
- Celecoxib
- Probenecid
- Thiazides
- Furosemide
- Sulfonylureas
Some Sulfa Allergies Cause PROblems. Thats FUR sure
Cytochrome p-450 inducers
Modafinil Chronic alcohol St. John’s wort Phenytoin Phenobarbital Nevirapine Rifampin Griseofulvin Carbamezapine
Some chronic alcoholics Steal Phen Phen and never Refuse Greasy Carbs
Antimicrobial Drugs names
- navir
- Ovir
- Ivir
-Protease inhibitor (Navir tease a PRO) -DNA polymerase inhibitor (Acyclovir) -Neuramindase inhibitor (oseltamivir)
CNS drug names:
- azine
- ipramine, triptyline
- triptan
- Zelma, zolam
- typical antipsychotic
- TCAs
- 5-HT agonist (sumatriptan)
- benzodiazepine
Autonomic drug names:
- chol
- curium, curonium
- olol
- stigmine
- terol
- zosin
- cholinergic agonist (Bethanechol, cabachol)
- Nondepolarizing paralytic; Atracurium, vecuronium
- B-blocker
- AChE inhibitor (neostigmine)
- B2 agonist (albuterol)
- A1 blocker (prazosin)
Drug names:
- Dronate
- gliptin
- glutazone
- Limus
- prazole
- prost
- sentan
- tidine
- tropin
- bisphosphonate (alendronate)
- DPP-4 inhibitors (sitagliptin)
- PPAR gamma activator (rosiglitazone)
- calcineurin inhibitor (eeverolimus, tacrolimus)
- PPI (omeprazole)
- Prostaglandin analog (Latanoprost)
- endothelium receptor antagonist (Bosentan)
- H2 blocker (Cimetidine)
- pituitary hormone (somatotropin)
Monoclonal antibodies:
- ximab
- zumab
- mumab
- chimeric human-mouse monoclonal antibody (Rituximab)
- Humanized mouse monoclonal Ab (bevacizumab)
- Human monoclonal Ab (Ipilmumab)
Drugs names that target Intracellular molecules:
- tinib
- zomib
- ciclib
- Tyrosine kinase inhibitor (imatinib)
- Proteosome inhibitor (Bortezomib)
- Cyclin dependent kinase ibhibitors (Palbociclib)
Drug names for Receptor fusion proteins:
-cept
-TNF-a blocker (Etanercept)
Interleukin receptor modulators (antagonists and agonists)
- leukin
- kinra
- IL-2 agonist/analog (Aldesleukin)
- Interleukin receptor blocker (anakinra)
Typical antipsychotics
-azines
- Haloperidol
- Pimozide
- trifluoperazine
- fluphenazine
- thioridazine
- chlorpromazine
“Typical az (azine) HAL
High potency typical antipsychotics
-Trifluoperazine,Fluphenazine
Haloperidol
(Try to Fly High)
-More neurological side effects; (extrapyramidal symptoms vs low potency antipsychotics)
Low potency typical antipsychotics
Chlorpromazine, thriodazine
- More anticholinergic, antihistamine, a1 blockade effects. (Vs high potency typical antipsychotics)
- Chlorpromazine-corneal deposits
- Thioridazine -retinal deposits
Typical antipsychotics Side Effects:
EPS (extrapyrimidal symptoms):
-Acute dystonia (Hours to days)
-Akathisia (restelessness)
-Parkinsonism (bradykinesia)
(Days to months)
-Tardive dyskinesia (months to years)
Tx of Tardive dyskinesia caused by typical antipsychotics
-Switch to atypical antipsychotics (clozapine, tetrabenazine, reserpine)
Atypical antipsychotics
- apine
- idone
- Schizophrenia negative and positive symptoms
- Give clonazine if:
- suicidal schizophrenia
- treatment resistent schizo
- schizoaffective disorder
Schizophrenia positive symptoms
- Delusions
- Hallucinaitons
- Disorganized speech
- Disorganized or catatonic behavior
Schizophrenic negative symptoms
- Affective flattening (lack of emotional expression)
- Avolition (lack of motivation)
- Anhedonia (lack of pleasure)
- Asociality
- Alogia (lack of personal content in speech, providing bare minimum communication)
Atypical antipsychotics side effects:
-“Pines”-metabolic syndrome (weight gain, DM, hyperlipidemia)
-Clozapine-agranulocytosis (CLozely monitor WBCs and seizures)
Risperidone-hyperprlactinemia (amenorrhea, galactorrhea, gynecomastia)
SNRI’s (serotonin and NE reputable inhibitors)
-mnemonic: SNRI DVDs with Mi Love.
Serious Nostalgia Renting Intimate DVD’s with Mi Love
Desvenlafaxine
Venlafaxine
Duloxetine
Milnacipran
Levmilnacipran
(Note: No other drugs in the antidepressant category start with D or V)
