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usmle > Antimycobacterial drugs > Flashcards

Antimycobacterial drugs Flashcards

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USMLE® Step 1 flashcards
1
Q

MOA: Inhibit DNA dependent RNA polymerase

A

Rifamycins; Rifampin and rifabutin

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2
Q

Bacterial catalase peroxidase (encoded by KatG) needed to convert drug into its active metabolite

A

Isoniazid (Decreases synthesis of mycolic acid)

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3
Q

This drug works best at acidic pH in host phagolysosomes

A

Pyrazinamide

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4
Q

Decrease carbohydrate polymerization by blocking arabinosyltransferase.

A

Ethambutol

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5
Q

Interferes with 30S component of ribosome

A

Streptomycin

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usmle (15 decks)

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