Diabetes Mellitis

Question 1

DM Drugs: Injectables

Answer 1

1.Insulin preparations: (LAG)
Rapid acting (1 hour peak):
Lispro
Aspart
Glulisine 

2.Amylin analogs
Pramlinitide

3.GLP-1 analogs (LEG)
Exenatide
Liraglutide

Question 2

DM drugs that delay carbohydrate digestion = decrease postprandial hyperglycemia

Answer 2

Alpha glucosidase inhibitors;

Acarbose, miglitol

Question 3

Drugs that cause:

1. cell depolarization (inhibit ATP K+ channels = decrease K+ uptake by pancreatic cells)
2. Increase ca2+ influx

Answer 3

-Sulfonylureas
1st generation;
chlorpropamide
tolbutamide

2nd generation;
glimepiride
glipizide
glyburide

-Meglitinides

Question 4

Block reabsorption of glucose in proximal collecting tubules

Answer 4

Sodium-Glucose cotransporter 2 inhibitors:

Flozins

Question 5

Drugs that

1. increase insulin sensitivity levels of adiponectin.
2. regulate glucose metabolism and fatty acid storage

Answer 5

GlitaZones/thiazolidinediones

Question 6

Drugs that decrease glucagon release and gastric emptying, suppress appetite (increase satiety)

Answer 6

Amylin
GLP-1 analogs; Exenatide, Liraglutide
DPP-4 inhibitors; Gliptins

Question 7

Which diabetic drugs can cause pancreatitis

Answer 7

Exenatide
Liraglutide
(GLP-1 analogs)

Question 8

Which diabetes drugs are weight neutral

Answer 8

Linagliptin
Saxagliptin
(DPP-4 inhibitors

Question 9

Which diabetic drugs may have a delayed onset of action (several weeks)

Answer 9

Glitazones

Question 10

Which diabetic drugs have an increased risk of fractures

Answer 10

Glitazones

Question 11

Which diabetic drugs can cause glucosuria, UTIs, and vaginal yeast infections?

Answer 11

Sodium-glucose cotransporter 2 inhibitors:

Canagliflozin

Question 12

First generation sulfonylureas

Answer 12

Chlorpropamide

Tolbutamide

Question 13

Chlorpropamide side effects

Answer 13

Disulfiram like effects

Question 14

2nd generation sulfonylureas

Answer 14

Glimepiride
Glipizide
Glyburide