Cephalosporins

Question 1

Which cephalosporin drug has increased antipseudomonal activity?

Answer 1

Cefepime (4th generation)

Question 2

Which cephalosporin is given as a prophylactic treatment before surgery to prevent s.aureus wound infections?

Answer 2

cefazolin (first generation)

Question 3

Which generation of cephalosporins covers Listeria, MRSA and Enterococci?

Answer 3

5th generation (Ceftaroline)

Question 4

Which cephalosporins are able to cross the blood brain barrier?

Answer 4

Third generation ( ceftriaxone, cefotaxime, cefpodoxime, ceftazidime )

Question 5

What is the mechanism of resistance for cephalosporins?

Answer 5

Structural change in penicillin binding proteins

Question 6

First generation cephalosporins (cefazolin, cephalexin) target which microbes?

Answer 6

PEcK- Proteus mirabilis, E.Coli, Klebsiella

Question 7

2nd generation cephalosporins (cefaclor, cefoxitine, cefuroxime) target which microbes

Answer 7

HENS PEcK

H. Influenza, Enterobacter aerogenes, Neisseria app. , Serratia Marcesens, proteus mirabilis, E.coli, Klebsiella

Question 8

3rd generation cephalosporins (Ceftriaxone, cefotaxime, cefpodoxime, ceftazidime) target which microbes?

Answer 8

Ceftriaxone: meminigitis, gonorrhea, disseminated Lyme disease.
Ceftazidime: pseudomonas
-3rd generation crosses blood brain barrier.

Question 9

4th generation cephalosporins (cefepime) target which microbes?

Answer 9

Increased pseudomonas activity and gram positive, emperic therapy, nosocomial pneumonia.