Pharmacology Flashcards
Route of administration of UFH prophylaxis?
Subcutaneous
Route of administration of UFH?
IV
Route of administration of LMW Heparin?
Subcutaneous
What could happen if heparin is given IM?
Hematoma
When is LMWH monitored?
Obesity
Pregnancy
Renal insufficiency
How is LMWH monitored ?
Anti Xa
What allergies should be checked before giving heparin?
Cow & pigs
Which surgery is heparin contraindicated in ?
Lumber puncture
What is the half life of fondaparinux ?
15 hours
How often should fondaparinux taken?
Once daily
What is fondaparinux indicated for ?
Venous thromboembolism
Univalent vs Bivalent direct thrombin inhibitors
Univalent: reversible & 1 site
Bivalent: irreversible & 2 sites
What do we give a patient with a history of HIT?
Argatroban
Route of administration of argatroban?
IV
Route of administration of dibagtron?
Oral
What is bivalirudin indicated for ?
Percutaneous coronary angioplasty
What is dibagatron indicated for?
Prophylaxis from venous thromboembolism in patients who underwent hip / knee replacement
What is heparin’s antidote?
Protamine
What is dibagatron antidote?
Idarucizumab
Route of administration of rivaroxiban?
Oral
What anticoagulant do we give patients with nonvalvular atrial fibrillation to prevent stroke?
Rivaroxaban / Apixaban
What anticoagulant do we give patients after knee/hip replacement to prevent venous thromboembolism?
Dibagatron / Rivaroxaban
What is the antidote for rivaroxaban?
andexanet alpha
What is the half life of warfarin?
36 hours
Why is warfarin contraindicated in hypothyroidism?
Slower turnover rate of clotting factors
What is cangrelor indicated for?
Coronary interventions
What is the administration route of cangrelor?
IV
What do we use for prophylaxis from thromboemboli for patients with prosthetic heart valves?
Warfarin + dipyridamol
What can be used for percutaneous coronary intervention?
Bivalirudin or Abciximab
What is the route of administration of GPIIb/IIIa inhibitors?
Parenteral
What can we use to prevent cerebrovascular ischemia ?
Aspirin + dipyridamol
What can we use for peripheral arterial disease?
Cilostazol / Vorapaxor
What is the antidote for fibrinolytic drugs?
Aminocaproic acid
What species is mycophenolate isolated from?
Penicillium glaucus
Anticoagulant with longest half life?
Vorapaxor
What anticoagulant do we use for acute cornoary syndrome
Ticagrelor + Aspirin
Or GP IIb/IIIa inhibitors