Leukemia

Question 1

What are B-ALL markers?

Answer 1

TdT+ & CD19,20,21+ & CD79a+
& CD10 & CD23

Question 2

What are T-ALL markers?

Answer 2

TdT+ & CD2+ & CD7+

Question 3

Peak age of B-ALL?

Answer 3

4 years

Question 4

Peak age of T-ALL?

Answer 4

15-20 years

Question 5

What mutation is mostly associated with B-ALL?

Answer 5

t(12;21) [TEL-AML1]

Question 6

What mutation is most associated with APML?

Answer 6

t(15;17) [PML-RARA]

Question 7

How is APML treated?

Answer 7

ATRA

Question 8

Which mutation is CML associated most with?

Answer 8

Philadelphia chromosome t(9;22) [ABL-BCR]

Question 9

What parts of the body does ALL treatment not reach?

Answer 9

Testes & CNS

Question 10

CD marker of T-ALL?

Answer 10

CD7

Question 11

Unique symptom of T-ALL?

Answer 11

Thymus mass (causes problem in breathing & superior vena cava)

Question 12

Unique CBC feature of CML?

Answer 12

WBC=100,000+

Question 13

What do CLL cells look on PB?

Answer 13

Smudge cell

Question 14

Which leukemia is associated with DIC?

Answer 14

APML (MPO released into blood)

Question 15

What leukemia is associated with AIHA?

Answer 15

CLL

Question 16

CD marker of hairy cell leukemia?

Answer 16

CD103

Question 17

Which leukemia has decreased immunoglobulin production?

Answer 17

CLL

Question 18

What is the translocation associated with AML M2 ?

Answer 18

t(8;21)

Question 19

What is the translocation associated with AML M4E ?

Answer 19

t(16;16)