Lymphoma

Question 1

What does the submandibular lymph node drain?

Answer 1

The face

Question 2

What does the preauricular lymph node drain?

Answer 2

Scalp & skin

Question 3

What does the epitrochlear lymph node drain?

Answer 3

Ulnar foreman & hands

Question 4

What antigens prove that reed-stenberg cells originated from b-lymphocytes?

Answer 4

PAX5 & MUM1

Question 5

How can identification of hodgkin cells help us ?

Answer 5

They help identify extra-nodal sites in known cases

Question 6

When is hodgkin lymphoma considered stage 1?

Answer 6

1 nodal / extra-nodal region

Question 7

When is hodgkin lymphoma considered stage 2?

Answer 7

2 nodal regions on the same side of the diaphragm

Question 8

When is hodgkin lymphoma considered stage 3?

Answer 8

Nodal regions on both sides of diaphragm + spleen maybe

Question 9

When is hodgkin lymphoma considered stage 4?

Answer 9

Diffuse extralymphatic disease

Question 10

% of SLL in NHL?

Answer 10

4%

Question 11

What is the transformation of SLL into DLCL called?

Answer 11

Richter’s transformation

Question 12

% of Folicular lymphoma patients from all NHL?

Answer 12

40%

Question 13

What mutation causes most of follicular lymphomas?

Answer 13

BCL2 on chr. 18 translocating into chr. 14 (Heavy Ig)
t [14:18]

Question 14

What identifies grade 1 follicular lymphoma ?

Answer 14

0-5 centroblasts

Question 15

What identifies grade 2 follicular lymphoma ?

Answer 15

6-15 centroblasts

Question 16

What identifies grade 3 follicular lymphoma ?

Answer 16

> 15 centroblasts

Question 17

% of mantle cell lymphoma patients out of all NHL patients?

Answer 17

5%

Question 18

What mutation causes mantle cell lymphomas?

Answer 18

Cyclin D1 on chr. 11 translocates to chr. 14 (Heavy Ig)
t [11;14]

Question 19

% of DLCL out of all NHL patients?

Answer 19

20%

Question 20

What mutations causes diffuse large cell lymphomas?

Answer 20

30% by BCL6 point mutation
30% by BCL2 over-expression

Question 21

What mutation causes burkitt lymphoma?

Answer 21

Translocation of c-myc on chr. 8 to chr. 14 (heavy Ig)
t [8;14]

Question 22

What causes B-symptoms ?

Answer 22

Reactive cells

Question 23

CD markers of classical Hodgkin lymphoma

Answer 23

CD15 & CD30

Question 24

What is the RS cell type found in Nodular sclerosing Hodgkin lymphoma ?

Answer 24

Lacunar cells

Question 25

What is the reactive cell type found in Nodular sclerosing Hodgkin lymphoma ?

Answer 25

Fibroblasts

Question 26

What is the RS cell type found in Nodular lymphocyte predominant Hodgkin lymphoma ?

Answer 26

Popcorn cell (PL)

Question 27

Symptoms of Hodgkin lymphoma?

Answer 27

Painless lymphadenopathy & B-symptoms

Question 28

What type of lymphocytes is reactive in hodgkin lymphoma?

Answer 28

T- helper cells