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HLS > Chemotherapy > Flashcards

Chemotherapy Flashcards

1
Q

What is the MOPP regimen composed of?

A

Mechlorethamine
Oncovin (vincristine)
Procarbazine
Prednisone

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2
Q

What is the ABVD regimen composed of?

A

Adriamycin
Bleomycin
Vinblastine
Dacarbazine

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3
Q

Why is mopp not used anymore?

A

Long term complications

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4
Q

When is HSCT done for cancer patients ?

A

Lack of complete remission
Or relapse before 1 year

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5
Q

When is Brentuximab vedotin used (AAVD)?

A

With or without HSCT for patients with failed treatment

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6
Q

What is the target of rituximab?

A

B-cell CD20

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7
Q

What is RCHOP regiment composed from?

A

Rituximab
Cyclophosphamide
Doxorubicin
Oncovin (vincristine)
Prednisone

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8
Q

How many cycles is RCHOPP done for?

A

4-6

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9
Q

What is ALL maintenance therapy?

A

Methotrexate + Mercaptopurine
(Maybe monthly vin & cortico)

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10
Q

What type of GVH is glucocorticoid used for?

A

1st line

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11
Q

What type of GVH are calcineurin inhibitors used for?

A

Cadaver

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12
Q

What type of GVH is sirulimus used for?

A

Steroid refractory

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13
Q

What side effects do all immunosuppressants share?

A

HTN & headaches

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14
Q

What is mycophenolate used as a first line for?

A

Chronic allograft vasculopathy in cardiac transplant

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15
Q

What side effect does tacrolimus have that is not seen in cyclosporin?

A

Diabetes mellitus (from hyperglycemia)

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16
Q

How does cyclosporin supress T-cells?

A

Cyclosporin-Cyclophillin inhibits calcineurin which inhibits NFAT which inhibits IL production

17
Q

How does Tacrolimus inhibit T-cells?

A

Tacrolimus-FKBP inhibits calcineurin which inhibits NFAT which inhibits IL production

18
Q

How do Sirulimus & Everolimus inhibit T-cells?

A

They bind with FK506BP12 which inhibits mTOR which inhibits IL production

19
Q

How does Tofacitinib work?

A

It inhibits JAK enzyme which reduces NK ,immunoglobulins & C-reactive proteins in the blood

20
Q

What is tofactinib used for ?

A

Severe Rheumatoid arthritis

21
Q

What is tofactinib’s black box for?

A

Infections & malignancy

22
Q

How does thialidomide work?

A

1) It decreases TNF & IL-10 thus decreasing neutrophils
2) increase T-cell activity

23
Q

How does azathioprine work?

A

Inhibits purine production

24
Q

How does cyclophosphamide work?

A

Alkylating agent

25
Q

How do leflunomide & teriflunomide work?

A

Inhibiting dihydrooratate dehydrogenase and thus inhibiting pyrimidine metabolism

26
Q

What is the 1st line choice for rheumatoid arthritis?

A

Methotrexate

27
Q

What is the use of hydrochloroquine?

A

Rheumatoid arthritis with mild side effects

28
Q

What does vinblastine do?

A

Prevent histamine degranulation

29
Q

What do we give patients allergic to azathioprine?

A

Methotrexate

HLS (13 decks)

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