Pharmacology Flashcards
Antibiotic that concentrations in the urine
Ampicillin
antimicrobial choice for actinomyces
penicillin
Diuretics
MALTS
M - mannitol - osmotic diuresis
A - acetazolamide - proximal tubule - carbonic anhydrase inhibitor PT
L - loop diuretic (furosemide) - thick ascending loop of Henle - blocks Na/K/2Cl transporter
T - thiazide - distal convoluted tubule/collecting ducks - blocks Na/Cl cotransporter
S - spironolactone - K sparing - collecting duck
TMS inhibits what
folic acid synthesis
Where in the kidneys are aminoglycosides toxic
proximal tubules
What is the mechanism of action of how heparin affects hemostasis
potential antithrombin III
What is the area under the curve
definite integral of a curve that describes the variation of a drug concentrations in blood plasma as a function of time
What is the elimination half life
the time it takes for the concentration of the drug in the plasma or the total amount in the body to be reduced by 50%
What enzyme does sildenafil inhibit
phosphodiesterase 5
MOA lidocaine
Na channel blocker
MOA leflunomide
pyrimidine synthesis inhibitor
How do you treat boxer granulomatous colitis (histiocytic ulcerative colitis)
enrofloxacin
MOA pimobendan
phosphodiesterase 3 inhibitor & and enhances sensitivity to Ca
SE of desmopressin
eye irritation, hypersensitivity reaction, hypernatremia with overdose
MOA entyce
Ghrelin receptor agonist
MOA trilostane
competitive inhibitor of 3-beta hydroxysteroid dehydrogenase
SE of oclacitinib (apoquel)
diarrhea
PPA
alpha agonist in urethra
What are the main principles of reducing antimicrobial resistance
????
MOA penicillin
beta lactam - inhibit mucopolypeptide synthesis in the cell wall
What is the action by the liver in phase II drug metabolism
glucuronidation
What is step 2 in drug detoxification
Conjugation
