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General Boards > Pharmacology > Flashcards

Pharmacology Flashcards

1
Q

Antibiotic that concentrations in the urine

A

Ampicillin

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2
Q

antimicrobial choice for actinomyces

A

penicillin

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3
Q

Diuretics

A

MALTS

M - mannitol - osmotic diuresis
A - acetazolamide - proximal tubule - carbonic anhydrase inhibitor PT
L - loop diuretic (furosemide) - thick ascending loop of Henle - blocks Na/K/2Cl transporter
T - thiazide - distal convoluted tubule/collecting ducks - blocks Na/Cl cotransporter
S - spironolactone - K sparing - collecting duck

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4
Q

TMS inhibits what

A

folic acid synthesis

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5
Q

Where in the kidneys are aminoglycosides toxic

A

proximal tubules

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6
Q

What is the mechanism of action of how heparin affects hemostasis

A

potential antithrombin III

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7
Q

What is the area under the curve

A

definite integral of a curve that describes the variation of a drug concentrations in blood plasma as a function of time

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8
Q

What is the elimination half life

A

the time it takes for the concentration of the drug in the plasma or the total amount in the body to be reduced by 50%

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9
Q

What enzyme does sildenafil inhibit

A

phosphodiesterase 5

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10
Q

MOA lidocaine

A

Na channel blocker

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11
Q

MOA leflunomide

A

pyrimidine synthesis inhibitor

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12
Q

How do you treat boxer granulomatous colitis (histiocytic ulcerative colitis)

A

enrofloxacin

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13
Q

MOA pimobendan

A

phosphodiesterase 3 inhibitor & and enhances sensitivity to Ca

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14
Q

SE of desmopressin

A

eye irritation, hypersensitivity reaction, hypernatremia with overdose

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15
Q

MOA entyce

A

Ghrelin receptor agonist

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16
Q

MOA trilostane

A

competitive inhibitor of 3-beta hydroxysteroid dehydrogenase

17
Q

SE of oclacitinib (apoquel)

A

diarrhea

18
Q

PPA

A

alpha agonist in urethra

19
Q

What are the main principles of reducing antimicrobial resistance

A

????

20
Q

MOA penicillin

A

beta lactam - inhibit mucopolypeptide synthesis in the cell wall

21
Q

What is the action by the liver in phase II drug metabolism

A

glucuronidation

22
Q

What is step 2 in drug detoxification

A

Conjugation

General Boards (15 decks)

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