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General Boards > Oncology > Flashcards

Oncology Flashcards

1
Q

What is the treatment for pheochromocytoma

A

phenoxybenzamine

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2
Q

What is the main prognostic factor with pituitary tumors

A

neurological signs

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3
Q

What distinguishes ALL and LSA

A

CD34

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4
Q

What are B-cell markers

A

CD21, CD20, and CD79

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5
Q

What does Elspar cause

A

hypersensitivity

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6
Q

What is the treatment for splenic mast cell tumor in cats

A

splenectomy

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7
Q

What do vinca alkaloids inhibit

A

metaphase

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8
Q

What is the most important prognostic factor in lymphoid neoplasi

A

immunophenotyping

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9
Q

What do you give a dog with LSA while waiting on MDR testing

A

cytoxan

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10
Q

Marker of malignancy

A

high nuclear to cytoplasmic ratio

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11
Q

What does metronomic chemo target

A

angiogenesis

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12
Q

What is target cell with metronomic chemo

A

Treg cells (down regulates number and function)

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13
Q

GIST (gastrointestinal stromal tumor)

A

high cKIT expression

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14
Q

What tumors is grade prognostic

A

STS, MCT, LSA, mammary carcinoma

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15
Q

What is the gompertzian growth

A

small tumors grow faster and rapidly dividing cells are more responsive to chemo

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16
Q

What are clin path findings you will see with tumor lysis syndrome

A

elevated K and P
uric acid in urine
hypocalcemia

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17
Q

Which chemo can cause hypersensitivity after multiple doses

A

Elspar

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18
Q

What chemo can you use while waiting for MDR testing

A

Cyclophosphamide

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19
Q

What chemos are MDR

A

doxorubricin, vincrisitine, vinblastine, actinomycin D, taxane

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20
Q

What is the MOA of mitoxantrone

A

topoisomerase inhibitor

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21
Q

What is MESNA used for

A

to prevent sterile hemorrhagic cystitis with cyclophosphamide (cytoxan) - acrolein metabolite

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22
Q

What chemos work in the M phase

A

vinka alkaloids (vincristine, vinblastine) and taxanes

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23
Q

MOA cytosine

A

anti-metabolite - pyrimidine analog that inhibits DNA polymerase

S-phase

24
Q

What do tyrosine kinase inhibitors work with feline vaccine associated sarcomas

A

Due to PDGF and p53 mutation

25
Q

What chemotherapy penetrate the BBB

A

CCNU, cytosine, 5-FU

26
Q

Drug that is directly toxic to islet cells in insulinoma

A

streptozotocin

Can also treat with steroids, diazoxide, and octreotide

27
Q

What chemo works in the M phase

A

vincristine, vinblastine, taxanes

28
Q

MOA cisplastin

A

crosslinking DNA

29
Q

Most common met to the brain

A

HSA

30
Q

Cancers that can cause hypoglycemia

A

insulinoma, leiomyosarcoma, lymphoma, HCC

31
Q

Dog with cranial abdominal pain, hypoglycemia, and stomach mass

A

leiomyosarcoma

32
Q

Clin path findings of hemophagocytic histiocytic sarcoma

A

low alb, low cholesterol, anemia (not coombs positive)

33
Q

Dog with bone pain and high globulins

A

MM

34
Q

cat with glistening skin and alopecia on ventrum

A

pancreatic or biliary carcinoma

35
Q

most common skin tumor in cats

A

basal cell carcinoma

36
Q

pulmonary carcinoma prognostic factors

A

size, CS, lymph node mets, pleural effusion, differentiation

37
Q

most likely tumor in cat with high calcium

A

SCC

38
Q

paraneoplastic syndrome with sertoli cell tumor

A

estrogen toxicity

39
Q

Mammary tumor prognostic factors

A

dog - ductal/inflammatory type, ulcerations, invasion, age, grade, mets, lack of estrogen

cat - AgNOR, Ki67, stage, lymphatic invasion, size

40
Q

prognosis for mandibular OSA

A

better than appendicular with surgery alone - less risk of mets

41
Q

best stain for MCT

A

giemsas and toludine blue

42
Q

Cat splenic MCT diagnosis

A

eosinophils

tx- splenectomy, chemo, TKI

43
Q

how do you differentiate ALL and stage V lymphoma

A

CD34 flow cytometry

44
Q

negative prognostic indicator in cats with large cell GI lymphoma

A

tumor grade

45
Q

CNS lymphoma in cats

A

associated with renal lymphoma, often you, FeLV positive

46
Q

prognostic factors for lymphoma dog

A

T-cell, substrage B, hyperCa, mediastinal, stage V, CNS involvement, poor response to chemo

47
Q

FeLV has a 60x increased risk of what tumor

A

LSA (t-cell

48
Q

FIV gives a 5x risk of what cancer

A

LSA (b-cell)

49
Q

Prognostic indicators for lymphoma

A

stage of disease, immunophenotyping, hyperCa, p-glycoprotein

50
Q

Dog with 75% HCT treatment

A

hydroxyurea

51
Q

Most common cause for migrating necrotizing dermatitis

A

glucagonoma

52
Q

MOA methotrexate

A

Folate analog

53
Q

which of the following targets mTOR

A

sirolimus (rapamycin)

54
Q

PARR - multiple bands present in dog with lymphadenopathy

A

inflammatory disease

55
Q

What is the most important prognostic factor for lymphoid neoplasi

A

immunophenotyping

56
Q

negative prognostic indicator for macroadenoma

A

neuro signs

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