Oncology

Question 1

What is the treatment for pheochromocytoma

Answer 1

phenoxybenzamine

Question 2

What is the main prognostic factor with pituitary tumors

Answer 2

neurological signs

Question 3

What distinguishes ALL and LSA

Answer 3

CD34

Question 4

What are B-cell markers

Answer 4

CD21, CD20, and CD79

Question 5

What does Elspar cause

Answer 5

hypersensitivity

Question 6

What is the treatment for splenic mast cell tumor in cats

Answer 6

splenectomy

Question 7

What do vinca alkaloids inhibit

Answer 7

metaphase

Question 8

What is the most important prognostic factor in lymphoid neoplasi

Answer 8

immunophenotyping

Question 9

What do you give a dog with LSA while waiting on MDR testing

Answer 9

cytoxan

Question 10

Marker of malignancy

Answer 10

high nuclear to cytoplasmic ratio

Question 11

What does metronomic chemo target

Answer 11

angiogenesis

Question 12

What is target cell with metronomic chemo

Answer 12

Treg cells (down regulates number and function)

Question 13

GIST (gastrointestinal stromal tumor)

Answer 13

high cKIT expression

Question 14

What tumors is grade prognostic

Answer 14

STS, MCT, LSA, mammary carcinoma

Question 15

What is the gompertzian growth

Answer 15

small tumors grow faster and rapidly dividing cells are more responsive to chemo

Question 16

What are clin path findings you will see with tumor lysis syndrome

Answer 16

elevated K and P
uric acid in urine
hypocalcemia

Question 17

Which chemo can cause hypersensitivity after multiple doses

Answer 17

Elspar

Question 18

What chemo can you use while waiting for MDR testing

Answer 18

Cyclophosphamide

Question 19

What chemos are MDR

Answer 19

doxorubricin, vincrisitine, vinblastine, actinomycin D, taxane

Question 20

What is the MOA of mitoxantrone

Answer 20

topoisomerase inhibitor

Question 21

What is MESNA used for

Answer 21

to prevent sterile hemorrhagic cystitis with cyclophosphamide (cytoxan) - acrolein metabolite

Question 22

What chemos work in the M phase

Answer 22

vinka alkaloids (vincristine, vinblastine) and taxanes

Question 23

MOA cytosine

Answer 23

anti-metabolite - pyrimidine analog that inhibits DNA polymerase

S-phase

Question 24

What do tyrosine kinase inhibitors work with feline vaccine associated sarcomas

Answer 24

Due to PDGF and p53 mutation

Question 25

What chemotherapy penetrate the BBB

Answer 25

CCNU, cytosine, 5-FU

Question 26

Drug that is directly toxic to islet cells in insulinoma

Answer 26

streptozotocin Can also treat with steroids, diazoxide, and octreotide

Question 27

What chemo works in the M phase

Answer 27

vincristine, vinblastine, taxanes

Question 28

MOA cisplastin

Answer 28

crosslinking DNA

Question 29

Most common met to the brain

Answer 29

HSA

Question 30

Cancers that can cause hypoglycemia

Answer 30

insulinoma, leiomyosarcoma, lymphoma, HCC

Question 31

Dog with cranial abdominal pain, hypoglycemia, and stomach mass

Answer 31

leiomyosarcoma

Question 32

Clin path findings of hemophagocytic histiocytic sarcoma

Answer 32

low alb, low cholesterol, anemia (not coombs positive)

Question 33

Dog with bone pain and high globulins

Answer 33

MM

Question 34

cat with glistening skin and alopecia on ventrum

Answer 34

pancreatic or biliary carcinoma

Question 35

most common skin tumor in cats

Answer 35

basal cell carcinoma

Question 36

pulmonary carcinoma prognostic factors

Answer 36

size, CS, lymph node mets, pleural effusion, differentiation

Question 37

most likely tumor in cat with high calcium

Answer 37

SCC

Question 38

paraneoplastic syndrome with sertoli cell tumor

Answer 38

estrogen toxicity

Question 39

Mammary tumor prognostic factors

Answer 39

dog - ductal/inflammatory type, ulcerations, invasion, age, grade, mets, lack of estrogen cat - AgNOR, Ki67, stage, lymphatic invasion, size

Question 40

prognosis for mandibular OSA

Answer 40

better than appendicular with surgery alone - less risk of mets

Question 41

best stain for MCT

Answer 41

giemsas and toludine blue

Question 42

Cat splenic MCT diagnosis

Answer 42

eosinophils tx- splenectomy, chemo, TKI

Question 43

how do you differentiate ALL and stage V lymphoma

Answer 43

CD34 flow cytometry

Question 44

negative prognostic indicator in cats with large cell GI lymphoma

Answer 44

tumor grade

Question 45

CNS lymphoma in cats

Answer 45

associated with renal lymphoma, often you, FeLV positive

Question 46

prognostic factors for lymphoma dog

Answer 46

T-cell, substrage B, hyperCa, mediastinal, stage V, CNS involvement, poor response to chemo

Question 47

FeLV has a 60x increased risk of what tumor

Answer 47

LSA (t-cell

Question 48

FIV gives a 5x risk of what cancer

Answer 48

LSA (b-cell)

Question 49

Prognostic indicators for lymphoma

Answer 49

stage of disease, immunophenotyping, hyperCa, p-glycoprotein

Question 50

Dog with 75% HCT treatment

Answer 50

hydroxyurea

Question 51

Most common cause for migrating necrotizing dermatitis

Answer 51

glucagonoma

Question 52

MOA methotrexate

Answer 52

Folate analog

Question 53

which of the following targets mTOR

Answer 53

sirolimus (rapamycin)

Question 54

PARR - multiple bands present in dog with lymphadenopathy

Answer 54

inflammatory disease

Question 55

What is the most important prognostic factor for lymphoid neoplasi

Answer 55

immunophenotyping

Question 56

negative prognostic indicator for macroadenoma

Answer 56

neuro signs