Pharmacology Flashcards
Mechanism of action of quinolones e.g. ciprofloxacin
inhibiting DNA synthesis and are bactericidal in nature
Adverse effects of quinolones: -floxacin
lowers seizure threshold
tendon damage
cartilage damage
lengthened QT interval
Causes of drug induced urinary retention? (5)
TCAs e.g. amitriptyline anticholinergics opioids NSAIDs disopyramide
Features of organophosphate poisoning:
SLUD salivation lacrimation urination defaecation
bradycardia, hypotension, small pupils, muscle fasciculation
Features of organophosphate poisoning:
SLUD salivation lacrimation urination defaecation
bradycardia, hypotension, small pupils, muscle fasciculation
Management of torsades de pointes:
IV magnesium sulphate
Common drug causes of urticaria:
NSAIDs
penicillins
aspirin
opiates
Management of BPH:
alpha blocker: tamsulosin / doxazosin
antiandrogen: finasteride
Digoxin toxicity features:
nausea and vomiting lethargy yellow-green tinged vision anorexia confusion arrhythmias gynaecomastia
Management of tricyclic antidepressant overdose:
IV sodium bicarbonate
TCA overdose features:
arrhythmias, seizures, metabolic acidosis, coma
acute onset tachycardia, sweating, fluctuating GCS
Symptoms of SSRI discontinuation:
increased mood change, restlessness, difficulty sleeping, unsteadiness, sweating, GI symptoms, paraesthesia
How often are lithium levels checked?
12 hours post dose every 3 months
What is used in cases of troublesome sleep paralysis?
clonazepam
