Haematology and Immunology Flashcards
What kind of anaemia does sickle cell cause?
normocytic anaemia with raised reticulocytes
Antiphospholipid syndrome in pregnancy: treatment
aspirin and LMWH (enoxaparin)
Antiphospholipid syndrome in pregnancy: treatment
aspirin and LMWH (enoxaparin)
What tumour has a ‘starry sky’ appearence?
Burkitt’s Lymphoma
Blood film: hyposplenism e.g. coeliac disease
target cells, howell-joly bodies, pappenheimer bodies, siderotic granules, acanthocytes
Blood film: IDA
target cells, pencil poikilocytes
What does sudden anaemia and low reticulocyte count indicate?
Parvovirus
Why are irradiated blood products used?
to avoid transfusion associated graft vs host disease
What anaemia is associated with beta-thalassaemia trait?
mild hypochromic, microcytic anaemia with raised bilirubin and raised reticulocytes
What two conditions show spherocytes on blood film?
Hereditary spherocytosis and autoimmune haemolytic anaemia
What does the direct coombs test test for?
autoimmune haemolytic anaemia
What does indirect Coombs test test for?
Rhesus haemolytic disease of the newborn
Immediate management of DIC?
4 units FFP and 10 units cryoprecipitate
Which factor deficiencies are haemophilia A and haemophilia B linked to?
Haemophilia A - factor VIII
Haemophilia B - factor IX
Features of haemophilia:
haemoarthroses, haematomas
prolonged bleeding after surgery / trauma
prolonged APTT
bleeding time, thrombin time, prothrombin time normal
