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MRCS PART A > Pharmacology > Flashcards

Pharmacology Flashcards

1
Q

Noradrenaline MOA

A

vasopressor
alpha-agonist
little effect on cardiac output

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2
Q

Adrenaline MOA

A

alpha + beta receptor agonists

increases cardiac output and systemic vascular resistance

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3
Q

Dopamine MOA

A

beta-1 agonist

increases contractility and rate

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4
Q

Dobutamine MOA

A

beta-1 and beta 2 agonist
increases cardiac output
decreases systemic vascular resistance

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5
Q

Milrinone MOA

A

phosphodiesterase inhibitor
vasodilator (so vasopressors commonly given with it)
short half life 1-2 hours

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6
Q

Commonly used inotropes (5)

A 
Noradrenaline
Adrenaline
Dopamine
Dobutamine
Milrinone
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7
Q

Adrenaline dose in anaphylaxis

A

1:1000 0.5mL IM

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8
Q

Pharmacological causes of oculogyric crisis (3)

A

Metoclopramide
Haloperidol
Phenothiazines

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9
Q

Mx of oculogyric crisis

A

Procyclidine

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10
Q

Common SE of antipyschotics

A

EPSE

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11
Q

Never use ?? in VT

A

verapamil

can precipitate VF

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12
Q

LA toxicity reversal

A

intralipid

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13
Q

Dose of lidocaine

A

3mg/kg

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14
Q

Dose of lidocaine + adrenaline

A

7mg/kg

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15
Q

Torsades de pointes Tx

A

IV magnesium sulphate

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16
Q

Ca channel blocker MOA

A

reduces tone of smooth muscle of vasculature, decreases SVR and BP

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17
Q

Alpha blocker MOA

A

inhibit alpha adrenergic receptors, decreases vascular tone, reduces SVR and BP

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18
Q

ACE-i MOA

A

blocks conversion of angiotensin I –> II

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19
Q

Warfarin inhibits which clotting factors

A

II, VII, IX, X (vit K dependent)

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20
Q

Drugs causing gynaecomastia

A 
DISCO
Digitalis
Isoniazid
Spironolactone
Cimetidine
Oestrogen
21
Q

Site of action of spironolactone

A

collecting duct in kidneys

22
Q

Site of action of furosemide

A

ascending loop of henle in kidneys

23
Q

LMWH MOA

A

binds antithrombin resulting in inhibition of factor Xa

24
Q

UFH MOA

A

binds antithrombin III which affects thrombin and factor Xa

25
Q

Warfarin reversal agent

A 
Vitamin K (4-24h)
Beriplex (1h)
26
Q

Lignocaine should not be used as LA in people with …?

A

unstable disorders of cardiac rhythm

27
Q

Cryoprecipitate major constituent

A

Factor VIII

28
Q

Benzodiazepine reversal agent

A

flumazenil

29
Q

Muscle relaxant induces generalised muscular contractions

A

suxamethonium

30
Q

Ciclosporin MOA

A

inhibit IL2 production in an activated T cell

31
Q

Tacrolimus MOA

A

inhibit IL2 production in an activated T cell

32
Q

Treatment for carcinoid syndrome

A

Octreotide

33
Q

methotrexate moa

A

interferes with DNA synthesis + repair + cellular replication

34
Q

SE ciclosporin

A

nephrotoxicity

35
Q

SE tacrolimus

A

diabetes

36
Q

Penicillins MOA

A

inhibit cell wall formation

37
Q

Macrolides MOA

A

inhibit bacterial protein synthesis

38
Q

Quinolones MOA

A

inhibit DNA synthesis

39
Q

Rifampicin MOA

A

inhibit RNA synthesis

40
Q

Lignocaine dose

A

3mg/kg

41
Q

Lignocaine + adrenaline dose

A

7mg/kg

42
Q

Depolarising muscle relaxant

A

suxamethonium

43
Q

Adrenaline receptors§

A

a-1, a-2, b-1, b-2

44
Q

Noradrenaline receptors

A

a-1 (a-2) (b-1) (b-2)

45
Q

Dobutamine receptors

A

b-1 (b-2)

46
Q

Dopamine receptors

A

(a-1) (a-2) (b-1) d-1 d-2

47
Q

heparin affects which clotting factors

A

antithrombin

factors 2,9,10,11,12

48
Q

warfarin affects which clotting factors

A

factor 2, 7, 9, 10 protein C

49
Q

TXA inhibits

A

plasmin

MRCS PART A (18 decks)

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