Pharmacology Flashcards
What are the Thyroid drugs?
Levothyroxine- T4
Liothyronine- T3
Adrenal steroids are also called?
Glucocorticoids
Goitre
Weight waxing
Cold intolerance
Myxoedema
Are symptoms of?
Hypothyroidism
Hypothyroidism
The thyroid gland does not produce enough thyroid
The half- life of Levothyroxine (T4) is prolonged by ?
Binding to TBG
Levothyroxine is considered a prodrug because
T4 converted to T3 in cell to act on a nuclear receptor
Which thyroid drug:
- Increased O2 consumption and heat production
- Increased cardiac muscle contractility
- Increased sensitivity to catecholamines
- Maintenance of hypoxic and hypercapnic drive in respiratory centre
- Increased gut motility
- Increased erythropoiesis
- Increased bone turnover
- Increased protein turnover and loss of muscle tissue
- Increased cholesterol degradation
- Increased metabolic turnover of many hormones and drugs
Levothyroxine
Overdose of Thyroxine cases?
diarrhoea, sweating, nervousness, tachycardia, increased appetite, loss of weight.
Overdose of thyroxine can lead to?
heart failure, angina, arrhythmia, osteoporosis (long term).
exophthalamos,
weight loss,
heat intolerance,
CVS increase
Are symptoms of?
Hyperthyroidism
Mechanism of action of inhibitors of Thyroperoxidase
Competitive inhibitors for substrate binding site on thyroperoxidase.
Inhibit the iodination of tyrosyl residues in thyroglobulin
What is also used to treat tachycardia/arrhythmia in hyperthyroidism?
B-blockers propranolol
What drug is used to treat :
- Cardiac arrest
- Anaphylaxis, angioedema – acute hypersensitivity (Epipen)
- Vasoconstrictor – local anaesthetics
- β-blockade - reduced response, hypertension, bradycardia
Epinephrine
Drug used to treat vasoconstriction in shock
Norepinephrine
Cortisol is a?
Glucocorticoid
