Neurotransmitrers

Question 1

What is synaptic transmission?

Answer 1

Chemical transmission between neurons

Question 2

What are types of ion channels for information signaling?

Answer 2

A. open (leak) ion channels: K+&raquo_space; Na+ and Cl-
B. closed (gated) ion channels GATED BY:
1. Voltage
2. Mechanical
3. Ligand (chemical substance)
amino acids: glutamate, glycine, GABA, aspartate

Question 3

What type of receptor protein is used in a slow reacrIon?

Answer 3

Neuromodulator substance

G-coupled reaction

Question 4

What type of substance is used for fast reactions?

Answer 4

Neurotransmitter substance

Substance binds to a receptor protein which is a direct-gated ion channel (also called
ionotropic or fast channel).

The response is fairly FAST and the action of the substance (either excitatory or inhibitory) depends on the filter selectivity of the ion channel.

Question 5

What is the Inhibitory amino acid transmitters in the CNS?

Answer 5

GABA
Glycine

They produce an IPSP (local inhibitory post synaptic potential)

Question 6

What releases GABA?

Answer 6

GABA is released by interneurons of cortex and midbrain

Question 7

Drug that block GABA produce?

Answer 7

Excitation and convulsion