Pharmacological treatment of angina Flashcards
What is the window for coronary flow in the heart
Where the aortic pressure is greater than ventricular pressure (coronary arteries are compressed in systole)
What shrinks the window for coronary blood flow?
• Shortening diastole
– e.g. increased heart rate
• Increased ventricular end diastolic pressure
– e.g. aortic valve stenosis
• Reduced diastolic arterial pressure
– e.g. mitral or aortic valve incompetence, heart failure
Discuss coronary ischaemia and infarction
• Coronary ischaemia usually the result of atherosclerosis
– Causes angina
• Sudden ischaemia is usually caused by thrombosis
– May result in cardiac infarction
• Coronary spasms sometimes causes angina
– “variant” angina
• Cellular calcium overload results from ischaemia
– may cause cell death and dysrhythmias
Discuss angina pectoris
• Chest pain due to inadequate supply of oxygen to the heart
– Typically severe and crushing
– “Tight, constricting, dull or heavy”
–SIGN Guidelines
• Characteristic distribution of pain
– Often retrosternal, or left side of chest and can radiate to left arm, neck, jaw and back
– Brought on by exertion, cold or excitement
– Thought chemical factors that cause pain in skeletal muscle (i.eK+,H+ and adenosine) are responsible
• Angina can accompany or be a precursor of a heart attack
What are the three classes of angina and what type of ischaemia are they associated with
Printzmetal’s variant angina (vasospasm)
- Supply ischaemia
Chronic stable angina (fixed stenosis)
-Demand ischaemia
Unstable angina (thrombus) -Supply ischaemia
Discus the angina classes
• Stable Angina
– Predictable chest pain on exertion
– Caused by a fixed narrowing of the coronary arteries
• Unstable Angina
– Occurs at rest and with less exertion than stable angina
– Associated with a thrombus around a ruptured atheromatous plaque
but without complete occlusion of the vessel (similar to MI)
• Variant (Prinzmetal) Angina
– Uncommon
– Caused by coronary artery spasm
– Not completely understood, but sometimes associated with atherosclerosis
What are some treatments to reduce chest pain symptoms?
– Beta-blockers – Nitrates – Calcium channel antagonists – Nirocandil (K+ channel activator) – Ivabradine (HCN Channel blocker) – Ranolazine (fatty acid oxygenation inhibitor(?))
(Don’t need to know brackets)
What are some treatments to prolong survival in those with angina
– Beta-blockers
– Aspirin
– Statins
– (Angiotensin Converting Enzyme Inhibitors)
– (AngiotensinII Receptor Blockers) - (ACEI or ARBs)
How do you treat symptoms of angina
• Offer short-acting nitrate for preventing/treating episodes of angina.
• Offer first-line treatment:
– Usually a β-blocker, but a calcium channel blocker (CCB)
can be considered.
- If control by β-blockers not optimal, addition of CCB can be considered.
- If beta blocker or CCB monotherapy ineffective and the other option is contraindicated, there are a few other drugs may be additionally used (e.g. nicorandil or ivabradine).
What is a short acting nitrate
Glyceryl trinitrate (GTN) tablets/spray
How do antianginal drugs work?
• Mainly work by ↓ the metabolic demand of the muscle
• Organic nitrates, nicorandil and calcium antagonists are vasodilators
– ↓ preload or afterload
• b-blockers and ivabradine slow down the heart
– ↓ the metabolic demand of the muscle
Discuss organic nitrates
• Glyceryl trinitrate and isosorbide mononitrate
– Powerful vasodilators
– Work by being metabolised to nitric oxide (NO) and relax smooth muscle (particular vascular smooth muscle)
– Act on veins to ↓ cardiac preload
• Higher concentrations can affect arteries, therefore ↓afterload
– ↓ cardiac workload is helped by dilaIon of collateral coronary vessels
• therefore improves distribution of coronary blood flow towards ischaemic areas
• Dilation of constricted coronary vessels is particularly beneficial in variant angina
(basically increases flow in arteries that bypass og)
Discuss clinical uses of organic nitrates in angina
• Stable Angina
– Prevention by sublingual glyceryl trinitrate shortly before
exertion or isosorbide mononitrate long before
• Unstable angina
– intravenous glyceryl trinitrate (GTN)
• Unwanted effects are common, headache and postural hypotension may occur
What are some other uses of organic nitrates (not angina)
• Acute heart failure (in specific circumstances)
– intravenous GTN
• Chronic Heart Failure (CHF)
– isosorbide mononitrate with hydralazine in patients of African origin especially, (or patient cannot tolerate more commonly used CHF drugs)
Discuss b(beta)-blockers
- Important (first line treatment) in the prophylaxis and treatment of stable and unstable angina
- ↓cardiac oxygen consumption by slowing the heart
- Also have an antidysrhythmic action – reduce death after MI
- Bisoprolol, Atenolol