Pharmacokinetics, Pharmacodynamics Flashcards
1
Q
What is the equation of clearance
A
Cl= Vd x K
2
Q
What is the equation of half life
A
t1/2= 0.7/k
3
Q
What is the equation for concentration
A
D/ Vd
4
Q
What is zero order kinetics?
A
saturation kinetics
the same about of the drug will always constant
the half life is variable
5
Q
What is first order kinetics?
A
exponential kinetics
the half life is constant
elimination is based on the concentration in the blood
6
Q
What is the equation for steady state for indwelling catheters?
A
K0 (rate of infusion) / Cl
7
Q
What is the equation for discrete maintenance dose?
A
(MD/ tau)/ Cl
8
Q
what is the relationship between clearance and half life
A
inversely proportional
9
Q
What are the time and steady state statements
A
50%= 1 x half life 90% = 3.3 x half life 95% = 4-5 x half life 100% = >7 half life
