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Pharmacology > Antivirals > Flashcards

Antivirals Flashcards

1
Q

Interferons

A

immunomodulatory cytokine released from virus infected cells –> infection unregulated interferon synthesis

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2
Q

What is interferon alpha used to treat?

A 
hepatitis B & C 
hairy cell leukaemia 
malignant melanoma 
Kaposi sarcoma 
condyloma acuminata 
renal cell carcinoma
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3
Q

What are the side effects of interferon alpha ?

A

Flue like syndrome ( fatigue, tinnitus, retinopathy, confusion)
myelosuppression
SLE

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4
Q

What does interferon beta treat?

A

relapsing multiple sclerosis

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5
Q

What does interferon gamma treat?

A

CGD

by bursting macrophages

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6
Q

What does SVR depict in HCV?

A

HCV RNA not detected by PCR for 6 moths after stopping treatment –> negative activity

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7
Q

Ribavarin

A

guanine , nucleoside
gets phosphorylated 3 times
tx: HCV & RSV

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8
Q

What are the side effect of ribavirin

A

hemolytic anemia

teratogenic

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9
Q

Sofosbuvir

A

nucleoside analog

inhibit NS5B RNA dependent RNA polymerase –> decreased RNA production

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10
Q

SImepravir

A

NS3/4A protease inhibitor
inhibit cap 450
SE: photosensitivity & rash

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Pharmacology (15 decks)

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