Cholinergic Pharm

Question 1

What does M3 do to the glands

Answer 1

increase all secretions

Question 2

What does M3 do to the eye

Answer 2

contraction :miosis of sphincter papillae

contraction : accommodation for near vision- ciliary muscle

Question 3

What does M2 do to the heart

Answer 3

affects the SA & AV node

decreased rate of firing

Question 4

What does M3 do to the lungs

Answer 4

Bronchospasm

Question 5

What does M3 do to the GI/ GU systems

Answer 5

increase gut motility
increased voiding
detrusor contraction
trigone relaxation

Question 6

What does M3 do to blood vessels

Answer 6

dilation via NO

Question 7

Methacholine

Answer 7

Dx: brachial hyperactivity

Question 8

Bethanechol

Answer 8

Tx: paralytic ileum & urinary retention

Question 9

Carbachol

Answer 9

used as a miotic agent

Question 10

Pilocarpine

Answer 10

Used for glaucoma

Question 11

Rivastigmine

Answer 11

Alzheimer

Parkison

Question 12

Donezepil

Answer 12

Alzheimer

Question 13

Endrophonium

Answer 13

Ddx of myasthenia graves

Ddx cholinergic crisis

Question 14

Neostigmine

Pyridostigmine

Answer 14

Tx: myasthenia gratis
reversal of competitive
postoperative GI/GU retention

Question 15

Physostigmine

Answer 15

tx :atropine overdose

crosses BBB

Question 16

Atropine

Answer 16

anticholinergic 
Tx: antispasmodic 
anti secretory 
management of Achase inhibitor overdose 
antidiarrheal 
Opthalmology 
reverse Av block

Question 17

Troppicamide, Homatropin, cyclopentolate

Answer 17

Ophthalmology

Question 18

Iprtropium , Tiotropium

Answer 18

Asthma, COPD

Question 19

Scopolamine

Answer 19

motion sickness

Question 20

Benztropine, trihexyphenidyl

Answer 20

Parkinsonism

has extrapyramidal side effects with antipsychotics

Question 21

Oxybutynin, tolterodine

Answer 21

bladder spasm

urinary incotinience

Question 22

Dicyclomine

Answer 22

irritable bowel syndrome

Question 23

Varenicline

Answer 23

smoking cessation

Question 24

Succinylcholine

Answer 24

neuromuscular blocker

Question 25

What are the two ganglion blockers

Answer 25

hexamethonium & mecamylamine

Question 26

What are the tissues affected & the effects by Alpha 1

Answer 26

arterioles : increase TPR veins: increase preload radial muscle: constriction and mydriasis Kidney: decrease renin Liver: increase glycgenolysis Genitourinary: -bladder : increase sphincter tone , urinary retention Vas deferens: increase emission

Question 27

What are the tissues effects of alpha 2

Answer 27

decrease release of Ne at the synapse decrease insulin aggregation of platelets

Question 28

What is the effects of Beta 1

Answer 28

SA,AV: increase HR muscle: increase contractility , increase SV Kidney: increase renin ciliary body : increase aqueous humour

Question 29

What are the effects of Beta 2

Answer 29

vessels: vasodilation , decreased TPR bronchioles: bronchodilation uterus: relaxation Liver & adipose:lipolysis, glycogenolysis, gluconeogenesis