Pharmacokinetics & Pharmacodynamics

Question 1

1. This governs the concentration-effect part of the interaction
2. Deals with dose-concentration part

Answer 1

1. Pharmacodynamics

2. Pharmacokinetics

Question 2

Name the pharmacokinetic processes (3) that determine how rapidly and for how long the drug will appear at the target organ.

Answer 2

Absorption
Distribution
Elimination

Question 3

The 2 basic parameters of pharmacokinetic:

A. The measure of the ability of the body to eliminate the drug.

B. The measure of the apparent space in the body available to contain the drug.

Answer 3

A. Clearance

B. Volume of Distribution

Question 4

Two major sites of drug elimination (2)

Answer 4

Kidney and Liver

Question 5

Define renal clearance

Answer 5

Clearance of unchanged drug in the urine

Question 6

Defined as the fraction of unchanged drug reaching the systemic circulation following administration by any route.

Answer 6

Bioavailability

Question 7

Describe the bioavailability of a drug in terms of route:

A. Intravenous

B. Oral

Answer 7

A. Bioavailability is assumed to be equal to unity

B. Bioavailability may be less than 100% for two main reasons

       - incomplete extent of absorption
       - first-pass elimination

Question 8

Extent of Absorption
True or False:

Drugs may not be absorbed because of a reverse transporter associated with ___________?

Answer 8

True. P-glycoprotein.

Question 9

Rate of absorption is determined by what 2 factors?

Answer 9

• Site of administration

- Drug formulation