Antipsychotic Agents and Lithium Flashcards
What subtype of antipsychotic drug produces high incidence of EPS?
NEUROLEPTICS
True or False.
Clozapine is an atypical antipsychotic drug.
TRUE. BECAUSE IT DOESN’T HAVE EPS.
What serotonin receptors when stimulated has hallucinatory effects of antipsychotic drugs?
5-HT2a
What is the major excitatory neurotransmitter in the brain?
GLUTAMATE
What subfamilies of drug produce sedation and weight gain?
PHENOTHIAZINES (such as chlorpromazine)
A patient is on clozapine treatment, she discontinued it abruptly. What adverse effects she may suffer from?
MYOCARDITIS OR AGRANULOCYTOSIS
True medical emergencies.
PHARMACOKINETICS.
DOPAMINERGIC SYSTEMS:
What pathway is most closely related to behavior and psychosis?
MESOLIMBIC-MESOCORTICAL PATHWAY
PHARMACOKINETICS.
DOPAMINERGIC SYSTEMS:
Pathway that is involved in coordination of voluntary movement
NIGROSTRIATAL PATHWAY
PHARMACOKINETICS.
DOPAMINERGIC SYSTEMS:
Pathway that arise in the arcuate nuclei and periventricular neurons and releases dopamine in pituitary portal circulation.
TUBEROINFUNDIBULAR
PHARMACOKINETICS.
DOPAMINERGIC SYSTEMS:
Consist of neurons in the motor nucleus of the vagus. This system may be involved in eating behavior.
MEDULLARY-PERIVENTRICULAR
It is the most important unwanted effects of antipsychotic drug.
TARDIVE DYSKINESIA
A patient on THIORIDAZINE/chlorpromazine therapy develops browning of vision. What explains this symptom?
DEPOSITS ON ANTERIOR PORTION OF THE EYE MAINLY CORNEA AND LENS ARE COMMON COMPLICATION OF THIS THERAPY. “Retinal deposits”
What is neuroleptic malignant syndrome?
LIFE-THREATENING DISORDER OCCURRING IN PATIENT WHO ARE EXTREMELY SENSITIVE TO EPS.
Initial symptoms is MUSCLE RIGIDITY.
First agent shown to be useful in treatment of manic phase of bipolar disorder that was not an antipsychotic drug.
LITHIUM
Key symptoms of bipolar disorder in manic phase
EXCITEMENT HYPERACTIVITY IMPULSITIVITY DISINHIBITION AGGRESSION PSYCHOTIC SYMPTOMS COGNITIVE IMPAIRMENT DECREASED NEED FOR SLEEP
