NSAIDS and GOUT

Question 1

The lipoxygenase pathway of arachidonate metabolism yields what inflammatory mediator, which have powerful chemotactic effects on eos, neutro, macrophage, and promotes bronchoconstriction?

Answer 1

LEUKOTRIENES

Question 2

DMARDS accelerates bone damage associated with rheumatoid arthritis. True or false.

Answer 2

FALSE

Question 3

What drug irreversibly acetylates and blocks platelet cyclooxygenase?

Answer 3

ASPIRIN

Question 4

Nephrotoxicity of NSAIDs is due to?

Answer 4

INTERFERENCE WITH AUTOREGULATION OF RENAL BLOOD FLOW, WHICH IS MODULATED BY PROSTAGLANDIN

Question 5

Main adverse effect of aspirin at antithrombotic doses?

Answer 5

GASTRIC UPSET

GASTRIC AND DUODENAL ULCERS

Question 6

True or False.

Non-acetylated Salicylates do not inhibit platelet aggregation.

Answer 6

TRUE

Question 7

What coxib gives cardioprotective effects?

Answer 7

COX 1

Question 8

Celecoxib may cause rashes due to what reason?

Answer 8

IT HAS A SULFONAMIDE SIDE-CHAIN

Question 9

In doses of 2400mg/day, it has an equivalent 4g of aspirin in anti-inflammatory effect

Answer 9

IBUPROFEN

Question 10

What NSAID is effective in closing PDA in preterm infants? (As effective and as safe as indomethacin)

Answer 10

IBUPROFEN

Question 11

Gastrointestinal effect of indomethacin?

Answer 11

Pancreatitis

Question 12

A proprionic acid derivative that inhibits both COX and lipoxygenase.

Answer 12

KETOPROFEN

Question 13

The only nonacid NSAID in current use.

Converted to active acetic acid derivative in the body.

Answer 13

NABUMETONE

Question 14

A sulfoxide prodrug, used in rheumatic disease and also suppresses familial intestinal polyposis.

Answer 14

SULINDAC

Question 15

Principal mechanism of action of this drug at low dose is used in rheumatic disease. With secondary effects on polymorphonuclear chemotaxis.
Some effects in dihydrofolate reductase.

Answer 15

METHOTREXATE

Question 16

It is an active metabolite of phenacitin and is responsible for its analgesic effect.

Answer 16

ACETAMINOPHEN

Question 17

Drug used for prophylaxis of recurrent episodes of gouty arthritis. Often causes diarrhea.

Answer 17

COLCHICINE

Question 18

Reduces total uric acid body burden by inhibiting xanthine oxidase. Given in intercritical periods.

Answer 18

ALLOPURINOL

Question 19

First nonpurine inhibitor of xanthine oxidase.

It is a potent and selective inhibitor of xanthine oxidase, thereby reduces the formation of xanthine and uric acid.

Answer 19

FEBUXOSTAT