NSAIDS and GOUT Flashcards
The lipoxygenase pathway of arachidonate metabolism yields what inflammatory mediator, which have powerful chemotactic effects on eos, neutro, macrophage, and promotes bronchoconstriction?
LEUKOTRIENES
DMARDS accelerates bone damage associated with rheumatoid arthritis. True or false.
FALSE
What drug irreversibly acetylates and blocks platelet cyclooxygenase?
ASPIRIN
Nephrotoxicity of NSAIDs is due to?
INTERFERENCE WITH AUTOREGULATION OF RENAL BLOOD FLOW, WHICH IS MODULATED BY PROSTAGLANDIN
Main adverse effect of aspirin at antithrombotic doses?
GASTRIC UPSET
GASTRIC AND DUODENAL ULCERS
True or False.
Non-acetylated Salicylates do not inhibit platelet aggregation.
TRUE
What coxib gives cardioprotective effects?
COX 1
Celecoxib may cause rashes due to what reason?
IT HAS A SULFONAMIDE SIDE-CHAIN
In doses of 2400mg/day, it has an equivalent 4g of aspirin in anti-inflammatory effect
IBUPROFEN
What NSAID is effective in closing PDA in preterm infants? (As effective and as safe as indomethacin)
IBUPROFEN
Gastrointestinal effect of indomethacin?
Pancreatitis
A proprionic acid derivative that inhibits both COX and lipoxygenase.
KETOPROFEN
The only nonacid NSAID in current use.
Converted to active acetic acid derivative in the body.
NABUMETONE
A sulfoxide prodrug, used in rheumatic disease and also suppresses familial intestinal polyposis.
SULINDAC
Principal mechanism of action of this drug at low dose is used in rheumatic disease. With secondary effects on polymorphonuclear chemotaxis.
Some effects in dihydrofolate reductase.
METHOTREXATE
It is an active metabolite of phenacitin and is responsible for its analgesic effect.
ACETAMINOPHEN
Drug used for prophylaxis of recurrent episodes of gouty arthritis. Often causes diarrhea.
COLCHICINE
Reduces total uric acid body burden by inhibiting xanthine oxidase. Given in intercritical periods.
ALLOPURINOL
First nonpurine inhibitor of xanthine oxidase.
It is a potent and selective inhibitor of xanthine oxidase, thereby reduces the formation of xanthine and uric acid.
FEBUXOSTAT
