Pharmacokinetics (Exam 1)

Question 1

Pharmacokinetics

Answer 1

Dose required to give proper concentration of the drug in target tissue

Question 2

What is the standard dose of drug based on?

Answer 2

Average ability to absorb, distribute, metabolize, and eliminate drug

Question 3

Phase I Metabolism

Answer 3

Produce a more polar molecule that is easier to eliminate, can sometimes result in a more toxic substance

Question 4

Phase II Metabolism

Answer 4

Links the drug to more polar molecules to render them even easier to excrete
Most commonly detoxify

Question 5

Passive Diffusion

Answer 5

Diffuse across plasma membrane from region of high concentration to low concentration

Question 6

Facilitated Diffusion

Answer 6

Carrier molecule assists in passive diffusion

Question 7

Active Transport

Answer 7

Requires energy and can transport against concentration gradient

Question 8

Pinocytosis

Answer 8

Endocytosis in which small particles in extracellular fluid are brought into cell via invagination and formation of a vesicle (active process)

Question 9

Absorption

Answer 9

Movement of a drug from its site of administration into systemic circulation

Question 10

Locations of Drug Absorption in GI Tract

Answer 10

Oral mucosa
Stomach
Small intestine
Large intestine

Question 11

Factors affecting absorption

Answer 11

Lipophilicity/Hydrophilicity
Size of the drug
Susceptibility to digestive enzymes or acidic conditions
Substrate for efflux pumps
Type of drug