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Pharmacology > Dopaminergic and Serotonergic (Exam 1) > Flashcards

Dopaminergic and Serotonergic (Exam 1) Flashcards

1
Q

Serotonergic

A

Serotonin Neurotransmitter

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2
Q

Serotonin

A

Monoamine found in CNS and enterochromaffin cells

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3
Q

Serotonergic receptors

A

5HT1-5HT7

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4
Q

Dopaminergic

A

Dopamine Neurotransmitter

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5
Q

Dopamine

A

Monoamine neurotransmitter found in brain, adrenal medulla, and GI tract

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6
Q

Dopaminergic Receptors

A

D1-D5

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7
Q

Indolamines

A

Serotonin, melatonin

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8
Q

MAO-A

A

Norepinephrine and serotonin breakdown

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9
Q

MAO-B

A

Dopamine breakdown

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10
Q

Serotonin 5HT1 (A, B, D, E, F, P) Receptors

A

Gi

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11
Q

Serotonin 5HT2 (A, B, C) Receptors

A

Gq

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12
Q

Serotonin 5HT3 (A, B, C, D, E) Receptors

A

LGIC (mostly Na+)

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13
Q

Serotonin 5HT4 Receptors

A

Gs

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14
Q

Serotonin 5HT5 (A) Receptors

A

Gi

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15
Q

Serotonin 5HT6 Receptors

A

Gs

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16
Q

Serotonin 5HT7 Receptors

A

Gs

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17
Q

Tryptophan

A

Synthesizes 5HT

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18
Q

5-HIAA

A

Major metabolite of serotonin excreted in urine

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19
Q

SERT (Serotonin Transporter)

A

Reuptake into presynaptic terminal

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20
Q

Where are 5HT1 receptors located?

A

Presynaptically as autoreceptors

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21
Q

CNS Serotonin

A

Tryptophan actively transported into brain by LAT1 to synthesize serotonin

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21
Q

PNS Serotonin

A

Synthesized by enterochromaffin cells of GI tract

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22
Q

How is serotonin in the brain produced?

A

By neurons originating in raphe nuclei

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23
Q

Serotonin signaling in the brain is important for (5)

A

Mood Regulation
Eating Behaviors
Emetic Response
Cognition
Sleep-wake

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24
Mood Regulation
Reduction in serotonergic signaling may lead to depression
25
Activation of 5HT2A Receptors
Causes hallucinations/delusions
26
Eating behaviors
Drugs that enhance serotonergic signaling may cause weight gain 5HT2 agonists can lead to weight loss
27
Emetic (Vomiting) response
Signaling through 5HT3 in chemoreceptor trigger zone enhances this
28
Serotonergic Signaling in Spinal Cord
Reduce pain perception
29
Enteric Nervous System (ENS)
Controls serotonergic signaling in the GI tract
30
5HT4 Activation
Enhanced intestinal peristalsis and faster gastric emptying
31
Platelet Effect
Activation of 5HT2A receptors on platelets weakly enhances platelet aggregation
32
Vasculature Effect
Activation of serotonergic receptors on blood vessels primarily leads to vasoconstriction
33
Drugs that inhibit SERT
Slightly increase bleed risk by reducing platelet serotonin storage
34
SSRIs
Inhibit serotonin transporter
35
Serotonergic syndrome (SS)
Excessive serotonergic signaling May occur due to drug interaction
36
Symptoms of SS
Agitation, confusion, restlessness Vasoconstriction, nausea, vomiting Fever Muscle twitching and spasms
37
SERT Inhibitors (SSRIs)
Enhance serotonergic signaling in brain Used for depression
38
5HT3 Receptor Antagonists (Setrons)
Reduce nausea and vomiting by antagonizing receptor in GI tract and at CTZ Treats nausea and vomiting
39
5HT1B/1D Receptor Agonists (Triptans)
Cause vasoconstrictions of cerebral vascular Treats migraines
40
CNS Dopamine Synthesis
Tyrosine and L-DOPA must be actively transported across BBB by transporter LAT1 Dopamine cannot cross BBB
41
PNS Dopamine synthesis
Neuroendocrine cells found in tissues synthesize dopamine
42
Homovanillic Acid (HVA)
Major metabolite for dopamine
43
Dopamine D1, D5 Receptors
Gs
44
Dopamine D2, D3, D4 Receptors
Gi
45
DAT (Dopamine Transporter)
Responsible for uptake in storage vesicles
46
A = Nigrostriatal Pathway
Increased dopamine can lead to hyperkinesia Decreased dopamine can lead to bradykinesia
47
B = Mesolimbic Pathway "Reward Pathway"
Euphoria and feelings of reward Increased dopamine leads to hallucinations
48
C = Mesocortical Pathway
Increased dopamine can increase cognition and emotional affect Decreased dopamine impairs cognitive and emotional affect
49
D = Tuberoinfundibular Pathway
Dopamine inhibits prolactin release Decreased dopamine leads to galactorrhea and gynecomastia
50
Parkinson's Disease (PD)
Loss of dopamine-containing substantia nigra neurons
51
Pathophysiology of PD
Balance between dopaminergic and cholinergic signaling is disrupted
52
D2 Receptor Antagonists
Reduce hallucinations in mesolimbic pathway - schizophrenia Reduce nausea/vomiting in CTZ Increase gastric motility
53
Addictive Drugs
Enhance dopaminergic release in mesolimbic pathway
54
DAT/NET/VMAT Inhibitors (Amphetamines)
Increase release of DA and NE in brain Treatment of ADHD
55
NET Inhibitors (SNRIs)
Enhance serotonergic and adrenergic signaling in CNS Treats depression and neuropathic pain
56
MAO Inhibitors
Non-selective inhibitors breakdown serotonin, NE, and DA Treats depression
57
D2 Receptor Antagonists
Reduces hallucinations and delusions Treats schizophrenia
58
Thyrotropin-releasing hormone (TRH)
Stimulates prolactin secretions while dopamine inhibits
59
Dopamine receptor agonists
Activate dopaminergic receptors in nigrostriatal pathway Treats PD and Restless Leg
60
Levodopa/Carbidopa
Increases dopamine in CNS Treats PD
61
MAO-B inhibitors
Reduce breakdown of dopamine Treats PD
62
COMT inhibitors
Reduce breakdown of dopamine Treats PD
63
Cardiovascular Dopamine
Activates D1 receptors leading to vasodilation High concentrations activate beta1 and alpha1 receptors
64
Kidney Dopamine
Activation leads to increased sodium and water exce4rtion
65
GI tract Dopamine
Activation decreases gastric motility
66
Dopamines affinity for dopaminergic and adrenergic receptors
Dopamine receptors >> beta >> alpha
67
Dopamine can act as a substrate for
NET

Pharmacology (18 decks)

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