Pharmacokinetics

Question 1

Only Free and non-charged drug can diffuse during the ____ ____ part of the nephron filtration cycle

Answer 1

Tubular Reabsorption

Question 2

Informal Bioavailability equation

Answer 2

Mouth concentration/ IV concentration

Question 3

Kd formula (fractional rate of drug loss from the body)

Answer 3

CLbody/Vd

Question 4

Volume of Distribution formula

Answer 4

Question 5

Two solutions if Half-life is doubled due to renal impairment

Answer 5

1. . Reduce Dose by Half
2. Double the dosing interval

Question 6

In the kidney, _____ filtration only allows free drug to pass, regardless of pKa or Lipophilicity

Answer 6

Glomerular

Question 7

Clearance Definition

Answer 7

Rate of Elimination/ Plasma Concentration

Question 8

The higher the value of _____, also known as the _______ coefficient, the more readily the drug will pass through GI epithelial membranes

Answer 8

P, Lipid:Water

(Hydrophobicity)

Question 9

_____ doses should be equal to the effective dose of the drug

Answer 9

Maintenance

Question 10

How do you adjust The rate/clearance formulas for Renal failure?

Answer 10

Creatnine Clearance (failure)/ Creatinine Clearance (normal multplied by Renal Clearance

Question 11

pH in the Intestine is around ____ to ____

Answer 11

5.3, 5.4

Question 12

For the ____ ____ part of the nephron filtration cycle, drugs that are free OR bound can be transported

Answer 12

Tubular Secretion

Question 13

Clearance of an organ formula

Answer 13

CLorgan= Organ Plasma flow x Extraction Ratio

Question 14

How much absoprtion and distribution occurs in IV?

Answer 14

None (100% Bioavailability)

Question 15

Give a loading dose ____ times the effective dose of the drug

Answer 15

2