Pharmacodynamics and Receptors Flashcards
Pilch: 1. Compare and contrast the efficacies and potencies of drugs on the basis of their graded dose-response curves. 2. Describe the difference between an agonist and a partial agonist. 3. Describe the different mechanisms of antagonism in clinical pharmacology. 4. Specify whether an antagonist is competitive or noncompetitive (irreversible) based on its effect on the graded dose-response curve of an agonist. 5. Specify whether a tissue contains spare receptors for an agonist based on the imp
High Kd means ____ affinity
low
The Y-axis of a Quantal Dose-response curve is ________
% Individuals Responding (ppl showing effect: yes/no)
Spare receptors make noncompetitive antagonists initially appear as ______ antagonists
Competitive
Therapeutic Index
TD50/ED50
Low Kd means _____ affinity
High
EC50
Effective drug CONCENTRATION that elicits 50% Max Effect
Potency is determined by _____, whereas Efficacy is determined by _____.
- EC50 - Emax
Spare receptors ______ tissue sensitivity to the drug
Increase
What happens to Emax and EC50 in Noncompetitive Antagonism?
Emax Dips, EC50 stays the same
On a drug curve, why can’t you measure Antagonists on the X axis?
Because relative effect is determined by [Activator]
What type of antagonist? What is altered?
Competitive, alters EC50
