Clinical Decision Making

Question 1

Two types of studies best for examining rare disease/side-effects

Answer 1

1. Pharmacoepidem
2. Case-control

Question 2

There are two studies to best answer Diagnoses; if there is a “follow-up”, then you would want to use a ______ study

Answer 2

Large prospective Cohort

Question 3

Treatment Threshold question for Clinical-decision making

Answer 3

Post-test prob to be comfortable to treat (more toxic means higher)

Question 4

Retrospective cohort studies are good for _____ ___

Answer 4

Hypothesis generating

Question 5

Testing Threshold question for Clinical-decision making

Answer 5

Post-test prob to be comfortable not treating pt. (More serious means lower)

Question 6

There are two studies to best answer Diagnoses; if there are multiple Reference Standard Testing, then you would want to use a ______ study

Answer 6

Cross-sectional

Question 7

Best study for prognosis?

Answer 7

Cohort study

Question 8

What is a useless LR?

Answer 8

1

Question 9

Best study for showing improved mortality?

Answer 9

RCT

Question 10

A perfect LR+ is _____, whereas a perfect LR- is _____

Answer 10

>10, <0.1

Question 11

Instead of RCT, you might have to choose a prospective cohort if _____ _____

Answer 11

Harmful treatment

Question 12

LR- formula and verbal explanation

Answer 12

Chance of - test in diseased
Chance of - test in normal

(1-sensitivity)/specificity

Question 13

Name 3 studies better than RCTS (least to most best)

Answer 13

1. Critical Article Synopsis
2. Critical Topic Synthesis
3. Systematic Reviews

Question 14

LR+ formula and verbal explanation

Answer 14

Chance of + test in diseased
Chance of + test in normal

Sensitivity/ (1- specificity)