Clinical Decision Making Flashcards

Dr. Willet

1
Q

Two types of studies best for examining rare disease/side-effects

A
  1. Pharmacoepidem
  2. Case-control
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2
Q

There are two studies to best answer Diagnoses; if there is a “follow-up”, then you would want to use a ______ study

A

Large prospective Cohort

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3
Q

Treatment Threshold question for Clinical-decision making

A

Post-test prob to be comfortable to treat (more toxic means higher)

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4
Q

Retrospective cohort studies are good for _____ ___

A

Hypothesis generating

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5
Q

Testing Threshold question for Clinical-decision making

A

Post-test prob to be comfortable not treating pt. (More serious means lower)

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6
Q

There are two studies to best answer Diagnoses; if there are multiple Reference Standard Testing, then you would want to use a ______ study

A

Cross-sectional

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7
Q

Best study for prognosis?

A

Cohort study

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8
Q

What is a useless LR?

A

1

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9
Q

Best study for showing improved mortality?

A

RCT

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10
Q

A perfect LR+ is _____, whereas a perfect LR- is _____

A

>10, <0.1

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11
Q

Instead of RCT, you might have to choose a prospective cohort if _____ _____

A

Harmful treatment

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12
Q

LR- formula and verbal explanation

A

Chance of - test in diseased
Chance of - test in normal

(1-sensitivity)/specificity

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13
Q

Name 3 studies better than RCTS (least to most best)

A
  1. Critical Article Synopsis
  2. Critical Topic Synthesis
  3. Systematic Reviews
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14
Q

LR+ formula and verbal explanation

A

Chance of + test in diseased
Chance of + test in normal

Sensitivity/ (1- specificity)

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